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绿茶及其成分对非酒精性脂肪肝的预防作用。

Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease.

机构信息

Department of Food Science , Rutgers University , New Brunswick , New Jersey , United States.

出版信息

J Agric Food Chem. 2019 May 15;67(19):5306-5317. doi: 10.1021/acs.jafc.8b05032. Epub 2019 Apr 1.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a typical chronic liver disease highly correlated with metabolic syndrome. Growing prevalence of NAFLD is supposed to be linked with the unhealthy lifestyle, especially high-calorie diet and lacking enough exercise. Currently, there is no validated pharmacological therapy for NAFLD except for weight reduction. However, many dietary strategies had preventive effects on the development of liver steatosis or its progression. As one of the most common beverages, green tea contains abundant bioactive compounds possessing antioxidant, lipid-lowering, and anti-inflammatory effects, as well as improving insulin resistance and gut dysbiosis that can alleviate the risk of NAFLD. Hence, in this review, we summarized the studies of green tea and its components on NAFLD from animal experiments and human interventions and discussed the potential mechanisms. Available evidence suggested that tea consumption is promising to prevent NAFLD, and further mechanisms and clinical studies need to be investigated.

摘要

非酒精性脂肪性肝病(NAFLD)是一种与代谢综合征高度相关的典型慢性肝病。随着不健康生活方式的流行,特别是高热量饮食和缺乏足够运动,NAFLD 的患病率不断上升。目前,除了减肥之外,NAFLD 没有经过验证的药物治疗方法。然而,许多饮食策略对肝脂肪变性的发展或其进展具有预防作用。作为最常见的饮料之一,绿茶含有丰富的具有抗氧化、降血脂和抗炎作用的生物活性化合物,以及改善胰岛素抵抗和肠道菌群失调,从而降低 NAFLD 的风险。因此,在这篇综述中,我们总结了绿茶及其成分在动物实验和人体干预中对 NAFLD 的研究,并讨论了潜在的机制。现有证据表明,饮茶有望预防 NAFLD,需要进一步开展机制和临床研究。

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