Li Honghe, Yan Xiaoqiang, Zhang Jitan, Guo Weicong, Jiang Jijun, Wang Jun
Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Angew Chem Int Ed Engl. 2019 May 13;58(20):6732-6736. doi: 10.1002/anie.201901619. Epub 2019 Apr 9.
The first enantioselective Satoh-Miura-type reaction is reported. A variety of C-N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C-H activation reaction of N-aryloxindoles and alkynes. High yields and enantioselectivities were obtained (up to 99 % yield and up to 99 % ee). To date, it is also the first example of the asymmetric synthesis of C-N axially chiral compounds by such a C-H activation strategy.
报道了首例对映选择性的佐藤-三浦型反应。通过铑催化的N-芳基氧化吲哚与炔烃的不对称双C-H活化反应，对映选择性地合成了多种C-N轴手性N-芳基氧化吲哚。反应获得了高产率和对映选择性（产率高达99%，对映体过量值高达99%）。迄今为止，这也是通过这种C-H活化策略对映选择性合成C-N轴手性化合物的首例。
