过氧化物酶体在癌症中的作用。
Peroxiporins in Cancer.
机构信息
Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.
Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso D'Augusto 237, 47921 Rimini, Italy.
出版信息
Int J Mol Sci. 2019 Mar 19;20(6):1371. doi: 10.3390/ijms20061371.
Abstract
The transport of H₂O₂ across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H₂O₂ can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H₂O₂ across biological membranes ("peroxiporins"), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.
摘要
水通道蛋白（AQP）跨膜转运 H₂O₂ 被认为是生物化学中过氧化氢发现历程的最后一个里程碑。根据其浓度和定位，H₂O₂ 可以作为旁分泌（细胞间）和/或自分泌（细胞内）信号，在各种细胞过程中既危险又可以作为信号分子。在这篇综述中，我们研究并批判性地检查了有关能够促进生物膜中 H₂O₂ 转运的 AQP 同工型（“过氧通道蛋白”）的现有信息，特别关注它们在癌症中的作用。此外，还示意性地报告和讨论了天然化合物调节过氧通道蛋白表达和/或活性的能力。
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