合成、体外抗菌和一些新的吡唑并[1,5-]嘧啶衍生物的细胞毒性活性。

Chemistry Department, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia.

Photochemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt.

Molecules. 2019 Mar 19;24(6):1080. doi: 10.3390/molecules24061080.

A new series of pyrazole ⁻ and pyrazolo[1,5-]pyrimidine ⁻ were synthesized by using a simple, efficient procedure, and screened for their in-vitro antimicrobial and antitumor activities. Symmetrical and asymmetrical 3,6-diarylazo-2,5,7-triaminopyrazolo[1,5-]pyrimidine were synthesized by the conventional method and also subjected to microwave irradiation and under ultrasound conditions. The biological results revealed that most of the tested compounds proved to be active as antibacterial and antifungal agents. The antitumor activity of the synthesized compounds was evaluated against human cancer cell lines, MCF-7, HCT-116, and HepG-2, as compared with Doxorubicin as a control.

通过采用简单高效的方法，合成了一系列新的吡唑并[1,5-a]嘧啶和吡唑并[1,5-a]嘧啶衍生物，并对它们的体外抗菌和抗肿瘤活性进行了筛选。通过常规方法合成了对称和不对称的 3,6-二芳基偶氮-2,5,7-三氨基吡唑并[1,5-a]嘧啶，并在微波辐射和超声条件下对其进行了处理。生物实验结果表明，大多数测试化合物都表现出了作为抗菌和抗真菌剂的活性。将所合成的化合物的抗肿瘤活性与作为对照的多柔比星(Doxorubicin)进行了比较，评估了它们对人癌细胞系 MCF-7、HCT-116 和 HepG-2 的抑制作用。