a Division of Pulmonary and Critical Care Medicine , Washington University School of Medicine , St. Louis , MO , USA.
Autophagy. 2019 Jun;15(6):1115-1116. doi: 10.1080/15548627.2019.1596498. Epub 2019 Mar 27.
Circadian rhythms help cells to organize complex processes, but how they shape the kinetics of protein catabolism is unclear. In a recent paper, we employed proteomics to map daily biological rhythms in autophagic flux in mouse liver, and correlated these rhythms with proteasome activity. We also explored the effect of inflammation caused by endotoxin on autophagy dynamics. Our data provide insight into how circadian rhythms serve as a framework for connecting the spatial, temporal, and metabolic aspects of autophagy at a system-wide level. Our observations also have implications for how to optimize autophagy-directed therapies in patients.
昼夜节律有助于细胞组织复杂的过程，但它们如何塑造蛋白质分解代谢的动力学尚不清楚。在最近的一篇论文中，我们采用蛋白质组学方法绘制了小鼠肝脏自噬通量的日常生物学节律图谱，并将这些节律与蛋白酶体活性相关联。我们还探讨了内毒素引起的炎症对自噬动力学的影响。我们的数据提供了深入了解昼夜节律如何作为一个框架，将自噬的空间、时间和代谢方面在系统水平上连接起来。我们的观察结果也对如何优化患者的自噬靶向治疗具有启示意义。
