Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Genome Med. 2019 Mar 20;11(1):15. doi: 10.1186/s13073-019-0629-7.
Circular RNAs (circRNAs) are 3'-5' covalently closed RNA rings produced from back-splicing of precursor mRNA in eukaryotes. Recent studies, using both computational and experimental approaches, have allowed advanced characterization of circRNAs, leading the research field into a new era and shedding light on the contribution of circRNAs to disease.
环状 RNA(circRNAs)是真核生物中由前体 mRNA 反向剪接产生的 3'至 5'共价闭合 RNA 环。最近的研究,结合计算和实验方法,使 circRNAs 的高级特征得以确定,将研究领域带入了一个新时代,并揭示了 circRNAs 对疾病的贡献。