环状RNA在SARS-CoV-2发病机制中的作用：潜在的诊断生物标志物和治疗靶点。
Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets.
作者信息
Wu JiaJie, Li Lele, Xu Wei, Xia Xiaoping, Wu Yingping
机构信息
Department of Clinical Laboratory, the Fourth Affiliated Hospital of School of medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
出版信息
Funct Integr Genomics. 2025 Jan 2;25(1):4. doi: 10.1007/s10142-024-01509-6.
Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prompting considerable interest and scrutiny from governmental and scholarly entities. Substantial research efforts have been dedicated to exploring diverse facets of this novel coronavirus, encompassing its pathogenesis, transmission dynamics, and therapeutic interventions. Recent findings suggest that circular RNAs (circRNAs) exert a pivotal influence on modulating viral infectivity and immune defense mechanisms. The detection of differentially expressed circRNAs in individuals afflicted with SARS-CoV-2 signifies a noteworthy advancement in understanding the molecular mechanisms underpinning viral pathogenesis.
自2019年12月以来，一种新型冠状病毒在全球传播，引发了一场重大的公共卫生危机，引起了政府和学术机构的广泛关注和审查。大量研究工作致力于探索这种新型冠状病毒的各个方面，包括其发病机制、传播动态和治疗干预措施。最近的研究结果表明，环状RNA（circRNAs）在调节病毒感染性和免疫防御机制方面发挥着关键作用。在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的个体中检测到差异表达的环状RNA，标志着在理解病毒发病机制的分子机制方面取得了显著进展。
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