Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, People's Republic of China.
Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People's Republic of China.
J Hematol Oncol. 2020 Oct 17;13(1):138. doi: 10.1186/s13045-020-00976-1.
With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recently identified as a type of regulatory RNAs. CircRNAs bind to certain miRNAs or proteins to participate in gene transcription and translation. Emerging evidence has indicated that the dysregulation of circRNAs is closely linked to the tumorigenesis and treatment response of hematological malignancies. CircRNAs play critical roles in various biological processes, including tumorigenesis, drug resistance, tumor metabolism, autophagy, pyroptosis, and ferroptosis. The N6-methyladenosine modification of circRNAs and discovery of fusion-circRNAs provide novel insights into the functions of circRNAs. Targeting circRNAs in hematological malignancies will be an attractive treatment strategy. In this review, we systematically summarize recent advances toward the novel functions and molecular mechanisms of circRNAs in hematological malignancies, and highlight the potential clinical applications of circRNAs as novel biomarkers and therapeutic targets for future exploration.
环状 RNA（circRNA）最初被误认为是 mRNA 剪接的副产物，因为它们具有共价闭合的环状结构。环状 RNA 是一类调控 RNA，具有丰富、稳定、高度保守和组织特异性等特点。环状 RNA 可以结合某些 miRNA 或蛋白质，参与基因转录和翻译。越来越多的证据表明，环状 RNA 的失调与血液系统恶性肿瘤的发生和治疗反应密切相关。环状 RNA 在肿瘤发生、药物耐药、肿瘤代谢、自噬、细胞焦亡和铁死亡等多种生物学过程中发挥重要作用。环状 RNA 的 N6-甲基腺苷修饰和融合环状 RNA 的发现为环状 RNA 的功能提供了新的见解。针对血液系统恶性肿瘤中的环状 RNA 可能是一种有吸引力的治疗策略。本综述系统总结了环状 RNA 在血液系统恶性肿瘤中的新型功能和分子机制的最新进展，并强调了环状 RNA 作为新型生物标志物和治疗靶点的潜在临床应用，以供未来探索。
