Neuroscience and Behavioral Disorders Programme, Duke-NUS Medical School, Singapore, Singapore.
Int Psychogeriatr. 2019 Oct;31(10):1499-1507. doi: 10.1017/S1041610218002089.
The apolipoprotein E (APOE) genotype provides information about Alzheimer's disease risk, yet genotype disclosure is discouraged due to concerns about possible distress. This is the first study investigating the psychological and behavioral impacts that genetic susceptibility testing for Alzheimer's disease has in an Asian population.
From March 2016 to November 2017, we ran a prospective cohort study at Duke-National University of Singapore Medical School. 280 healthy Chinese elderly filled in questionnaires that measured psychological symptoms and health behaviors, 1 week before and 6 weeks after APOE genotype disclosure. Responses from ε4-positive subjects (associated with greater Alzheimer's disease risk) were compared to responses from ε4-negative subjects.
ε4 presence was not significantly associated with anxiety (p = 0.09) or depression (p = 0.25). No associations were found for changes to diet (p = 0.36), dietary supplements consumption (p = 0.90), physical activity (p = 0.15), or cognitive activity (p = 0.18).
There is no evidence to suggest that disclosure of APOE to Asian populations was associated with any short-term adverse psychological or behavioral impacts.
载脂蛋白 E（APOE）基因型提供了关于阿尔茨海默病风险的信息，但由于担心可能会引起痛苦，因此不鼓励进行基因型检测。这是第一项针对亚洲人群进行的关于阿尔茨海默病遗传易感性检测的心理和行为影响的研究。
从 2016 年 3 月到 2017 年 11 月，我们在杜克-新加坡国立大学医学院进行了一项前瞻性队列研究。280 名健康的中国老年人在 APOE 基因型检测结果公布前一周和公布后六周填写了问卷，问卷内容涉及心理症状和健康行为。比较了 ε4 阳性（与更高的阿尔茨海默病风险相关）和 ε4 阴性受试者的回答。
ε4 阳性与焦虑（p = 0.09）或抑郁（p = 0.25）无关。饮食（p = 0.36）、膳食补充剂摄入（p = 0.90）、体育活动（p = 0.15）或认知活动（p = 0.18）的变化与 ε4 阳性也没有关联。
没有证据表明向亚洲人群披露 APOE 与任何短期的不良心理或行为影响有关。
