紊乱的血流会引起持续的、随机的 NF-κB 激活，这可能支持颅内动脉瘤在体内生长。

Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.

机构信息

Department Mechanical Engineering, University College London, London, UK.

Department Bioengineering, Imperial College London, London, UK.

出版信息

Sci Rep. 2019 Mar 18;9(1):4738. doi: 10.1038/s41598-019-40959-y.

Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown. Here, we show that (disturbed) shear stress induced by vortices is a sufficient condition to activate the endothelial NF-kB pathway, possibly through a mechanism of mechanosensor de-activation. We provide evidence for this statement through in-vitro live cell imaging of NF-kB in HUVECs exposed to different flow conditions, stochastic modelling of flow induced NF-kB activation and induction of disturbed flow in mouse carotid arteries. Finally, CFD and immunofluorescence on human intracranial aneurysms showed a correlation similar to the mouse vessels, suggesting that disturbed shear stress may lead to sustained NF-kB activation thereby offering an explanation for the close association between disturbed flow and intracranial aneurysms.

颅内动脉瘤与血流速度模式紊乱和慢性炎症有关，但这些发现的相关性目前尚不清楚。在这里，我们表明，涡流引起的（紊乱）切应力是激活血管内皮 NF-κB 途径的充分条件，可能通过机械感受器失活的机制。我们通过在不同流动条件下暴露于 NF-κB 的 HUVEC 的体外活细胞成像、流动诱导的 NF-κB 激活的随机建模以及在小鼠颈动脉中诱导紊乱流动，为这一说法提供了证据。最后，对人类颅内动脉瘤的 CFD 和免疫荧光分析显示出与小鼠血管相似的相关性，这表明紊乱的切应力可能导致 NF-κB 的持续激活，从而为血流紊乱与颅内动脉瘤之间的密切关系提供了解释。