Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Front Immunol. 2019 Mar 6;10:296. doi: 10.3389/fimmu.2019.00296. eCollection 2019.
The germinal center (GC) is a transient anatomical structure formed during the adaptive immune response that leads to antibody affinity maturation and serological memory. Recent works using two-photon microscopy reveals that the GC is a highly dynamic structure and GC B cells are highly motile. An efficient selection of high affinity B cells clones within the GC crucially relies on the interplay of proliferation, genome editing, cell-cell interaction, and migration. All these processes require actin cytoskeleton rearrangement to be well-coordinated. Dysregulated actin dynamics may impede on multiple stages during B cell affinity maturation, which could lead to aberrant GC response and result in autoimmunity and B cell malignancy. This review mainly focuses on the recent works that investigate the role of actin regulators during the GC response.
生发中心（GC）是适应性免疫应答过程中形成的一种短暂的解剖结构，导致抗体亲和力成熟和血清记忆。最近使用双光子显微镜的研究揭示，GC 是一个高度动态的结构，GC B 细胞具有高度的迁移能力。在 GC 中有效地选择高亲和力 B 细胞克隆，关键依赖于增殖、基因组编辑、细胞间相互作用和迁移的相互作用。所有这些过程都需要肌动蛋白细胞骨架的重新排列来进行良好的协调。肌动蛋白动力学的失调可能会阻碍 B 细胞亲和力成熟的多个阶段，这可能导致异常的 GC 反应，并导致自身免疫和 B 细胞恶性肿瘤。本综述主要关注研究 GC 反应过程中肌动蛋白调节剂作用的最新工作。
