三阴性乳腺癌中CD44、CD24和Ki67的维度分析
Dimensional Analysis of CD44 CD24 and Ki67 in Triple Negative Breast Cancer.
作者信息
Tan Betty, Kanoko Mpu, Tan Gino, Bachtiar Adang, Munir Delfitri
机构信息
Department of Anatomic Pathology of Medical Faculty, University of Sumatera Utara, Jl. Dr Mansyur No 5, Medan 20155, Indonesia.
Department of Anatomic Pathology of Medical Faculty, University of Indonesia, Jakarta, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Feb 27;7(4):526-528. doi: 10.3889/oamjms.2019.182. eCollection 2019 Feb 28.
AIM
To study the dimensional analysis CD44 CD24 and Ki67 in triple negative breast cancer (TNBC).
METHODS
This cross-sectional study was performed on patients with breast cancer in Haji Adam Malik Hospital Medan from 2013 to 2016 to determine the frequency and pathologic features of TNBC by immunohistochemistry stained.
RESULTS
By using immunohistochemistry staining panel of CD44, CD24, Twist, Claudin 7, CK5, CK8/18, EMA, E-Cadherin, Ki-67, a total 67 breast tumour samples with TNBC were classified as 9 stem-cells like 1 basal, 22 baso-luminal, and 23 luminal subtypes.
CONCLUSION
By using immunohistochemical staining panel, TNBC can be differentiated into stem cells like basal, baso-luminal and luminal subtypes. Didifferentiation and EMT can produce heterogeneity in TNBC subtypes and this will affect in handling TNBC. Stemness in stem cells- like subtypes are resistant to therapy. Therefore, TNBC needs special attention in order to assist in more optimal handling.
目的
研究三阴性乳腺癌（TNBC）中CD44、CD24和Ki67的维度分析。
方法
对2013年至2016年棉兰哈贾·亚当·马利克医院的乳腺癌患者进行了这项横断面研究，通过免疫组织化学染色确定TNBC的频率和病理特征。
结果
通过使用CD44、CD24、Twist、Claudin 7、CK5、CK8/18、EMA、E-钙黏蛋白、Ki-67免疫组织化学染色面板，总共67例TNBC乳腺肿瘤样本被分类为9例干细胞样、1例基底样、22例基底-腔面样和23例腔面样亚型。
结论
通过使用免疫组织化学染色面板，TNBC可分为干细胞样、基底样、基底-腔面样和腔面样亚型。去分化和上皮-间质转化可导致TNBC亚型的异质性，这将影响TNBC的治疗。干细胞样亚型中的干性对治疗有抗性。因此，TNBC需要特别关注，以协助进行更优化的治疗。
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