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三阴性乳腺癌中CD44、CD24和Ki67的维度分析

Dimensional Analysis of CD44 CD24 and Ki67 in Triple Negative Breast Cancer.

作者信息

Tan Betty, Kanoko Mpu, Tan Gino, Bachtiar Adang, Munir Delfitri

机构信息

Department of Anatomic Pathology of Medical Faculty, University of Sumatera Utara, Jl. Dr Mansyur No 5, Medan 20155, Indonesia.

Department of Anatomic Pathology of Medical Faculty, University of Indonesia, Jakarta, Indonesia.

出版信息

Open Access Maced J Med Sci. 2019 Feb 27;7(4):526-528. doi: 10.3889/oamjms.2019.182. eCollection 2019 Feb 28.

DOI:10.3889/oamjms.2019.182
PMID:30894906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6420956/
Abstract

AIM

To study the dimensional analysis CD44 CD24 and Ki67 in triple negative breast cancer (TNBC).

METHODS

This cross-sectional study was performed on patients with breast cancer in Haji Adam Malik Hospital Medan from 2013 to 2016 to determine the frequency and pathologic features of TNBC by immunohistochemistry stained.

RESULTS

By using immunohistochemistry staining panel of CD44, CD24, Twist, Claudin 7, CK5, CK8/18, EMA, E-Cadherin, Ki-67, a total 67 breast tumour samples with TNBC were classified as 9 stem-cells like 1 basal, 22 baso-luminal, and 23 luminal subtypes.

CONCLUSION

By using immunohistochemical staining panel, TNBC can be differentiated into stem cells like basal, baso-luminal and luminal subtypes. Didifferentiation and EMT can produce heterogeneity in TNBC subtypes and this will affect in handling TNBC. Stemness in stem cells- like subtypes are resistant to therapy. Therefore, TNBC needs special attention in order to assist in more optimal handling.

摘要

目的

研究三阴性乳腺癌（TNBC）中CD44、CD24和Ki67的维度分析。

方法

对2013年至2016年棉兰哈贾·亚当·马利克医院的乳腺癌患者进行了这项横断面研究，通过免疫组织化学染色确定TNBC的频率和病理特征。

结果

通过使用CD44、CD24、Twist、Claudin 7、CK5、CK8/18、EMA、E-钙黏蛋白、Ki-67免疫组织化学染色面板，总共67例TNBC乳腺肿瘤样本被分类为9例干细胞样、1例基底样、22例基底-腔面样和23例腔面样亚型。

结论

通过使用免疫组织化学染色面板，TNBC可分为干细胞样、基底样、基底-腔面样和腔面样亚型。去分化和上皮-间质转化可导致TNBC亚型的异质性，这将影响TNBC的治疗。干细胞样亚型中的干性对治疗有抗性。因此，TNBC需要特别关注，以协助进行更优化的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94a/6420956/35362e7395ee/OAMJMS-7-526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94a/6420956/35362e7395ee/OAMJMS-7-526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c94a/6420956/35362e7395ee/OAMJMS-7-526-g001.jpg

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本文引用的文献

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E-Cadherin as a diagnostic biomarker in breast cancer.E-钙黏蛋白作为乳腺癌的诊断生物标志物
N Am J Med Sci. 2011 May;3(5):227-33. doi: 10.4297/najms.2011.3227.
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Prognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast cancer.CD24 和 Claudin-7 免疫表达在导管浸润性乳腺癌中的预后意义。
Oncol Rep. 2012 Jan;27(1):28-38. doi: 10.3892/or.2011.1477. Epub 2011 Sep 28.
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CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome.
CD44(+)/CD24(-/low) 癌症干细胞/祖细胞在三阴性浸润性乳腺癌表型中更为丰富，并与不良预后相关。
Hum Pathol. 2012 Mar;43(3):364-73. doi: 10.1016/j.humpath.2011.05.005. Epub 2011 Aug 10.
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Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties.表达 CD44 的非小细胞肺癌细胞富含干细胞样特性。
PLoS One. 2010 Nov 19;5(11):e14062. doi: 10.1371/journal.pone.0014062.
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CD24: from A to Z.CD24：从 A 到 Z。
Cell Mol Immunol. 2010 Mar;7(2):100-3. doi: 10.1038/cmi.2009.119. Epub 2010 Feb 15.
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Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer.管腔B型乳腺癌患者的Ki67指数、HER2状态与预后
J Natl Cancer Inst. 2009 May 20;101(10):736-50. doi: 10.1093/jnci/djp082. Epub 2009 May 12.
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Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity.具有“三阴性”表型的乳腺浸润性导管癌：表皮生长因子受体免疫反应性的预后意义
Breast Cancer Res Treat. 2009 Jul;116(2):317-28. doi: 10.1007/s10549-008-0206-z. Epub 2008 Oct 7.
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Breast cancer stem cells: implications for therapy of breast cancer.乳腺癌干细胞：对乳腺癌治疗的启示
Breast Cancer Res. 2008;10(4):210. doi: 10.1186/bcr2111. Epub 2008 Jul 22.
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Interferon receptor alpha/beta is associated with improved survival after adjuvant therapy in resected pancreatic cancer.干扰素受体 α/β与接受辅助治疗的可切除胰腺癌患者的生存改善相关。
HPB (Oxford). 2007;9(4):289-94. doi: 10.1080/13651820701329241.
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ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.ETV6-NTRK3融合致癌基因通过激活AP1复合体，从定向乳腺祖细胞引发乳腺癌。
Cancer Cell. 2007 Dec;12(6):542-58. doi: 10.1016/j.ccr.2007.11.012.