• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重组人骨形态发生蛋白-2注入型可吸收胶原海绵、重组人骨形态发生蛋白-2包被的磷酸三钙以及富血小板纤维蛋白混合磷酸三钙用于兔鼻窦增高的比较。

Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits.

作者信息

Kim Chul-Hun, Ju Mi-Ha, Kim Bok-Joo

机构信息

Department of Oral and Maxillofacial Surgery, Assistant Professor, Dong-a Univ. College of Medicine, Busan, South Korea.

Department of Pathology, Faculty of Pathology, Dong-a University College of Medicine, Busan, South Korea.

出版信息

J Dent Sci. 2017 Sep;12(3):205-212. doi: 10.1016/j.jds.2017.01.003. Epub 2017 Apr 25.

DOI:10.1016/j.jds.2017.01.003
PMID:30895052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6400000/
Abstract

BACKGROUND/PURPOSE: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant human bone morphogenetic protein (rhBMP)-2, rhBMP-2-coated tricalcium phosphate (TCP), platelet-rich fibrin-mixed TCP for enhancing bone regeneration in sinus augmentation in rabbits.

MATERIALS AND METHODS

The sinus defects were grafted with rhBMP-2+ACS (Group A), rhBMP-2-coated TCP (Group B), and platelet-rich fibrin-mixed TCP (Group C). The specimens underwent decalcification, and were stained for histomorphometric analysis.

RESULTS

There were no significant differences in inflammatory features among the groups 1-week postoperation. In a histomorphometric analysis, the new bone formation ratio showed significant differences between groups at 2 weeks. rhBMP-2+ACS showed a larger and more rapid bone formation area at 2 weeks than those of Groups B and C.

CONCLUSION

Our histological evaluation demonstrates that Type I ACS can be used as a carrier of rhBMP-2, and rhBMP-2+ACS showed rapid bone formation, remodeling, and calcification at Week 2 in rabbit.

摘要

背景/目的：在种植牙科中，为了在上颌窦骨再生过程中获得足够量的新骨，已使用了多种移植材料。本研究的目的是比较浸渍有重组人骨形态发生蛋白（rhBMP）-2的I型可吸收胶原海绵（ACS）、rhBMP-2包被的磷酸三钙（TCP）、富含血小板纤维蛋白混合TCP在兔上颌窦提升术中促进骨再生的潜力。

材料与方法

用rhBMP-2+ACS（A组）、rhBMP-2包被的TCP（B组）和富含血小板纤维蛋白混合TCP（C组）移植鼻窦缺损处。标本进行脱钙处理，并进行组织形态计量学染色分析。

结果

术后1周时，各组间炎症特征无显著差异。组织形态计量学分析显示，2周时各组间新骨形成率存在显著差异。rhBMP-2+ACS在2周时的骨形成面积比B组和C组更大且更快。

结论

我们的组织学评估表明，I型ACS可作为rhBMP-2的载体，且rhBMP-2+ACS在兔实验中第2周时显示出快速的骨形成、重塑和钙化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/ee0a28420fa1/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/c7edb3ae48d2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/d975f7920678/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/dc77a892fb2e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/24f82b4be067/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/89cf75c99b2e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/e7b1ea069f33/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/ee0a28420fa1/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/c7edb3ae48d2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/d975f7920678/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/dc77a892fb2e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/24f82b4be067/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/89cf75c99b2e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/e7b1ea069f33/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a384/6400000/ee0a28420fa1/gr7.jpg

相似文献

1
Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits.重组人骨形态发生蛋白-2注入型可吸收胶原海绵、重组人骨形态发生蛋白-2包被的磷酸三钙以及富血小板纤维蛋白混合磷酸三钙用于兔鼻窦增高的比较。
J Dent Sci. 2017 Sep;12(3):205-212. doi: 10.1016/j.jds.2017.01.003. Epub 2017 Apr 25.
2
A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2-coated tricalcium phosphate and platelet-rich fibrin-mixed tricalcium phosphate in rabbits.兔鼻窦骨移植中重组人骨形态发生蛋白 2 涂层磷酸三钙与富含血小板纤维蛋白混合磷酸三钙的效果比较研究。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 May;113(5):583-92. doi: 10.1016/j.tripleo.2011.04.029. Epub 2011 Aug 10.
3
Synergism between recombinant human bone morphogenetic protein 2/absorbable collagen sponge and bone substitutes favors vertical bone augmentation and the resorption rate of the biomaterials: Histomorphometric and 3D microcomputed tomography analysis.重组人骨形态发生蛋白 2/可吸收胶原海绵与骨替代物之间的协同作用有利于垂直骨增量和生物材料的吸收率：组织形态计量学和 3D 微计算机断层扫描分析。
J Periodontol. 2020 Oct;91(10):1295-1306. doi: 10.1002/JPER.19-0571. Epub 2020 Mar 25.
4
Histologic and histomorphometric assessment of sinus-floor augmentation with beta-tricalcium phosphate alone or in combination with pure-platelet-rich plasma or platelet-rich fibrin: A randomized clinical trial.单纯β-磷酸三钙或联合富血小板血浆/富血小板纤维蛋白用于鼻窦底提升的组织学和组织形态计量学评估：一项随机临床试验。
Clin Implant Dent Relat Res. 2017 Oct;19(5):959-967. doi: 10.1111/cid.12522. Epub 2017 Jul 26.
5
Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects.重组人骨形态发生蛋白-4与载体对大鼠颅骨缺损的影响。
J Periodontol. 2003 Jun;74(6):787-97. doi: 10.1902/jop.2003.74.6.787.
6
Effect of recombinant human bone morphogenetic protein-2 on bone regeneration in large defects of the growing canine skull after dura mater replacement with a dura mater substitute.重组人骨形态发生蛋白-2 对硬脑膜替代物置换硬脑膜后生长犬颅骨大缺损骨再生的影响。
J Neurosurg. 2010 Feb;112(2):319-28. doi: 10.3171/2009.1.JNS08976.
7
Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers.以可吸收胶原海绵和β-磷酸三钙为载体与重组人骨形态发生蛋白-2相关的异位骨形成。
Biomaterials. 2005 May;26(15):2501-7. doi: 10.1016/j.biomaterials.2004.07.015.
8
Effect of recombinant human bone morphogenetic protein-4 dose on bone formation in a rat calvarial defect model.重组人骨形态发生蛋白-4剂量对大鼠颅骨缺损模型中骨形成的影响。
J Periodontol. 2004 Oct;75(10):1364-70. doi: 10.1902/jop.2004.75.10.1364.
9
Vertical Bone Augmentation Using Deproteinized Bovine Bone Mineral, Absorbable Collagen Sponge, and Recombinant Human Bone Morphogenetic Protein-2: An In Vivo Study in Rabbits.使用脱蛋白牛骨矿物质、可吸收胶原海绵和重组人骨形态发生蛋白-2进行垂直骨增量：一项在兔体内的研究
Int J Oral Maxillofac Implants. 2018 May/June;33(3):512–522. doi: 10.11607/jomi.5959. Epub 2018 Mar 15.
10
Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation.重组人骨形态发生蛋白-2/可吸收胶原海绵与自体骨移植用于上颌窦底提升的关键、随机、平行评估
J Oral Maxillofac Surg. 2009 Sep;67(9):1947-60. doi: 10.1016/j.joms.2009.04.085.

引用本文的文献

1
Reducing Healing Period with DDM/rhBMP-2 Grafting for Early Loading in Dental Implant Surgery.使用DDM/rhBMP-2移植减少种植牙手术早期负重的愈合期
Tissue Eng Regen Med. 2025 Feb;22(2):261-271. doi: 10.1007/s13770-024-00689-3. Epub 2025 Jan 18.
2
Tissue engineering applications of recombinant human collagen: a review of recent progress.重组人胶原蛋白的组织工程应用：近期进展综述
Front Bioeng Biotechnol. 2024 Feb 14;12:1358246. doi: 10.3389/fbioe.2024.1358246. eCollection 2024.
3
Assessment of rhBMP-2-loaded bovine hydroxyapatite granules in the guided bone regeneration of critical bone defect in rat mandible bone.

本文引用的文献

1
Maxillary sinus lift without grafting, and simultaneous implant placement: a prospective clinical study with a 51-month follow-up.不植骨的上颌窦提升术及同期种植体植入：一项为期51个月随访的前瞻性临床研究
Int J Oral Maxillofac Surg. 2015 Jul;44(7):902-7. doi: 10.1016/j.ijom.2015.03.016. Epub 2015 Apr 18.
2
Simultaneous sinus lift and implantation using platelet-rich fibrin as sole grafting material.使用富血小板纤维蛋白作为唯一移植材料同时进行上颌窦提升和种植。
J Craniomaxillofac Surg. 2014 Sep;42(6):990-4. doi: 10.1016/j.jcms.2014.01.021. Epub 2014 Jan 14.
3
Alveolar distraction osteogenesis versus autogenous onlay bone graft for vertical augmentation of severely atrophied alveolar ridges after 12 years of long-term follow-up.
负载重组人骨形态发生蛋白-2的牛羟基磷灰石颗粒在大鼠下颌骨临界骨缺损引导性骨再生中的评估
J Dent Sci. 2024 Jan;19(1):276-284. doi: 10.1016/j.jds.2023.04.016. Epub 2023 Apr 28.
4
Synthetic Calcium-Phosphate Materials for Bone Grafting.用于骨移植的合成磷酸钙材料
Polymers (Basel). 2023 Sep 19;15(18):3822. doi: 10.3390/polym15183822.
5
Effect of ErhBMP-2-loaded β-tricalcium phosphate on ulna defects in the osteoporosis rabbit model.负载ErhBMP-2的β-磷酸三钙对骨质疏松兔模型尺骨缺损的影响。
Bone Rep. 2020 Dec 10;14:100739. doi: 10.1016/j.bonr.2020.100739. eCollection 2021 Jun.
6
Regeneration of a Pediatric Alveolar Cleft Model Using Three-Dimensionally Printed Bioceramic Scaffolds and Osteogenic Agents: Comparison of Dipyridamole and rhBMP-2.使用三维打印生物陶瓷支架和成骨剂再生儿科牙槽裂模型：双嘧达莫和 rhBMP-2 的比较。
Plast Reconstr Surg. 2019 Aug;144(2):358-370. doi: 10.1097/PRS.0000000000005840.
肺泡牵张成骨与自体骨块游离移植在严重萎缩牙槽嵴垂直向增量中的 12 年长期随访比较。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Nov;116(5):540-9. doi: 10.1016/j.oooo.2013.06.037. Epub 2013 Sep 8.
4
A comparative study of the effectiveness of sinus bone grafting with recombinant human bone morphogenetic protein 2-coated tricalcium phosphate and platelet-rich fibrin-mixed tricalcium phosphate in rabbits.兔鼻窦骨移植中重组人骨形态发生蛋白 2 涂层磷酸三钙与富含血小板纤维蛋白混合磷酸三钙的效果比较研究。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 May;113(5):583-92. doi: 10.1016/j.tripleo.2011.04.029. Epub 2011 Aug 10.
5
Sinus augmentation using rhBMP-2/ACS in a mini-pig model: relative efficacy of autogenous fresh particulate iliac bone grafts.使用 rhBMP-2/ACS 在小型猪模型中进行鼻窦增大：自体新鲜颗粒髂骨移植物的相对疗效。
Clin Oral Implants Res. 2013 May;24(5):497-504. doi: 10.1111/j.1600-0501.2011.02419.x. Epub 2012 Jan 26.
6
Maxillary sinus lift with solely autogenous bone compared to a combination of autogenous bone and growth factors or (solely) bone substitutes. A systematic review.单纯自体骨与自体骨联合生长因子或（单纯）骨替代物行上颌窦提升的疗效比较：一项系统评价。
Int J Oral Maxillofac Surg. 2012 Feb;41(2):160-7. doi: 10.1016/j.ijom.2011.10.001. Epub 2011 Nov 17.
7
New bone formation in the maxillary sinus using peripheral venous blood alone.仅使用外周静脉血在上颌窦中形成新骨。
J Oral Maxillofac Surg. 2011 Sep;69(9):2357-67. doi: 10.1016/j.joms.2011.02.092. Epub 2011 Jun 30.
8
Comparison of clinical outcomes of sinus bone graft with simultaneous implant placement: 4-month and 6-month final prosthetic loading.同期植入种植体时进行上颌窦骨增量的临床效果比较：4个月和6个月的最终修复体加载
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Feb;111(2):164-9. doi: 10.1016/j.tripleo.2010.04.011. Epub 2010 Jul 24.
9
Clinical treatment of postoperative infection following sinus augmentation.上颌窦提升术后感染的临床治疗
J Periodontal Implant Sci. 2010 Jun;40(3):144-9. doi: 10.5051/jpis.2010.40.3.144. Epub 2010 Jun 25.
10
New bone formation in the maxillary sinus using only absorbable gelatin sponge.仅使用可吸收明胶海绵在上颌窦中形成新骨。
J Oral Maxillofac Surg. 2010 Jun;68(6):1327-33. doi: 10.1016/j.joms.2010.02.014.