肥胖青年在仰卧位和坐位时血压较高且心脏迷走神经活动较低。
Higher blood pressure and lower cardiac vagal activity in obese young individuals in supine and seated position.
作者信息
Lourenço Dias André Rodrigues, de Souza Katrice Almeida, de Jesus Lima de Sousa Laila Cândida, Dos Santos Kamila Meireles, Kolesny Tricot Gabriel, de Araújo Jaqueline Alves, Teresa Cambri Lucieli, Arsa Gisela
机构信息
Graduate Program on Physical Education, Federal University of Mato Grosso, Cuiaba, Mato Grosso, Brazil.
出版信息
J Clin Transl Res. 2017 Sep 23;3(3):328-337. eCollection 2018 Jan 15.
BACKGROUND
Obesity triggers alterations in hemodynamic and autonomic control. There are few studies that investigate the effects of overweight and obesity in early adulthood on hemodynamic and autonomic variables.
AIM
The aim of this study was to determine whether overweight and obesity in young individuals cause alterations in hemodynamic parameters and heart rate variability (HRV) in supine and seated position, and to correlate these variables with anthropometric features.
METHODS
Measurements were performed in 40 young untrained male study participants. The subjects were eutrophic (22.8 ± 0.3 kg/m, N = 19), overweight (27.0 ± 0.5 kg/m, N = 10), and obese (33.5 ± 0.8 kg/m, N = 11). After 5 min in supine and seated position, the R-R intervals and blood pressure (BP) were recorded.
RESULTS
The systolic blood pressure were higher in overweight (supine, 122.9 ± 2.3 mmHg) and obese (supine, 123.9 ± 2.2; seated, 121.7 ± 2.3 mmHg) individuals compared to eutrophic individuals (supine, 111.8 ± 1.64; seated, 111.3 ± 1.8 mmHg) (p ⩽ 0.05). Obese subjects exhibited lower HRV (SD1, RMSSD, pNN50) compared to eutrophic individuals when seated. In obese subjects, the heart rate (HR) increased and HRV decreased (p ≤ 0.05) when seated versus supine position. The body mass, body mass index (BMI), and waist and abdominal circumferences correlated positively with BP (r = 0.40-0.64, ≤ 0.05), while the BMI, waist circumference, BP, and HR were negatively correlated (r = -0.32 -0.62, ≤ 0.05) with HRV (pNN50 and HF) in both body positions. BMI, waist circumference, BP and HR correlated negat- ively with additional HRV indices (SD1, SD2, RMSSD, TP, and LF) when seated.
CONCLUSIONS
Obese and overweight individuals presented higher SBP, and obese individuals had lower HRV and cardiac vagal activity, associated with anthropometric variables.
RELEVANCE FOR PATIENTS
The monitoring of HRV in obese subjects in seated position allows improved prognosis of metabolic consequences to cardiac autonomic control.
背景
肥胖会引发血液动力学和自主神经控制的改变。很少有研究调查成年早期超重和肥胖对血液动力学和自主神经变量的影响。
目的
本研究的目的是确定年轻人中的超重和肥胖是否会导致仰卧位和坐位时血液动力学参数和心率变异性（HRV）的改变，并将这些变量与人体测量特征相关联。
方法
对40名未经训练的年轻男性研究参与者进行测量。受试者分为营养良好组（22.8±0.3kg/m²，N = 19）、超重组（27.0±0.5kg/m²，N = 10）和肥胖组（33.5±0.8kg/m²，N = 11）。在仰卧位和坐位5分钟后，记录RR间期和血压（BP）。
结果
与营养良好的个体（仰卧位，111.8±1.64；坐位，111.3±1.8mmHg）相比，超重个体（仰卧位，122.9±2.3mmHg）和肥胖个体（仰卧位，123.9±2.2；坐位，121.7±2.3mmHg）的收缩压更高（p≤0.05）。坐位时，肥胖受试者的HRV（SD1、RMSSD、pNN50）低于营养良好的个体。在肥胖受试者中，坐位与仰卧位相比，心率（HR）增加，HRV降低（p≤0.05）。体重、体重指数（BMI）、腰围和腹围与血压呈正相关（r = 0.40 - 0.64，p≤0.05），而BMI、腰围、血压和心率在两种体位下与HRV（pNN50和HF）呈负相关（r = -0.32 - 0.62，p≤0.05）。坐位时，BMI、腰围、血压和心率与其他HRV指标（SD1、SD2、RMSSD、TP和LF）呈负相关。
结论
肥胖和超重个体的收缩压较高，肥胖个体的HRV和心脏迷走神经活动较低，且与人体测量变量相关。
对患者的意义
监测肥胖受试者坐位时的HRV有助于改善心脏自主神经控制代谢后果的预后。
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