Ma Xiao, Zhang Hongying, Jia Jinhai
Department of Outpatient, Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Graduate School, Hebei Medical University, Shijiazhuang, Hebei 050011, China.
Asian Biomed (Res Rev News). 2025 Jul 28;19(3):131-140. doi: 10.2478/abm-2025-0016. eCollection 2025 Jun.
Garlic extracts have been demonstrated to be effective supplements for reducing blood pressure in hypertensive subjects. However, contradictory observations on the efficacy of garlic extracts have been reported in different studies.
To explore the efficacy of garlic, this study aimed to perform a meta-analysis of previously published controlled placebo trials and drew firm conclusions.
We searched online databases, including Scopus, PubMed, and Science Direct, to obtain relevant articles on the role of garlic in reducing blood pressure in patients with hypertension. The literature search, data extraction, and analysis were performed independently by two researchers. Comprehensive Meta-Analysis Software v4 was used for all the analyses.
Twelve reports, comprising 405 patients treated with garlic derivatives and 333 receiving placebo, were included in this investigation. The results of the meta-analysis revealed a significant decrease in systolic blood pressure (mean difference: -8.121, 95% confidence interval [CI]: -10.95 to -5.28, < 0.0001) and diastolic blood pressure (mean difference: -4.256, 95% CI: -5.99 to -2.52, < 0.0001) in subjects treated with garlic extracts compared to those treated with placebo. Interestingly, trial sequential analysis also supports the observations of the meta-analysis and indicates that a sufficient number of trials have already been performed to reach a consensus conclusion, and further trials are not required. In addition, the GRADEing of evidence also supports the robustness of the observations.
Garlic extracts significantly lower blood pressure and may be prescribed by clinicians for patients with hypertension.
大蒜提取物已被证明是高血压患者降低血压的有效补充剂。然而，不同研究报告了关于大蒜提取物功效的相互矛盾的观察结果。
为探究大蒜的功效，本研究旨在对先前发表的对照安慰剂试验进行荟萃分析并得出确切结论。
我们检索了在线数据库（包括Scopus、PubMed和ScienceDirect），以获取有关大蒜在高血压患者中降低血压作用的相关文章。文献检索、数据提取和分析由两名研究人员独立进行。所有分析均使用综合荟萃分析软件v4。
本调查纳入了12份报告，包括405例接受大蒜衍生物治疗的患者和333例接受安慰剂治疗的患者。荟萃分析结果显示，与接受安慰剂治疗的受试者相比，接受大蒜提取物治疗的受试者收缩压显著降低（平均差值：-8.121，95%置信区间[CI]：-10.95至-5.28，<0.0001），舒张压也显著降低（平均差值：-4.256，95%CI：-5.99至-2.52，<0.0001）。有趣的是，试验序贯分析也支持荟萃分析的观察结果，并表明已经进行了足够数量的试验以达成共识结论，无需进一步试验。此外，证据分级也支持观察结果的稳健性。
大蒜提取物可显著降低血压，临床医生可为高血压患者开具此类药物。
