Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Division of Nuclear Technology and Applications, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
Obes Surg. 2019 Jul;29(7):2191-2199. doi: 10.1007/s11695-019-03822-7.
Lateral and medial hypothalamus (LH and MH) play important roles in energy balance. Changed hypothalamic function has been found in subjects with obesity. However, the effect of bariatric surgery on the function of the two sub-regions has been poorly investigated.
Thirty-eight subjects with obesity and 34 age- and sex-matched normal-weight controls were included. Seventeen of the 38 subjects underwent laparoscopic sleeve gastrectomy. Functional magnetic resonance imaging data and metabolic parameters were collected to investigate functional connectivity networks of the two hypothalamic sub-regions as well as the influence of sleeve gastrectomy on the two networks in subjects with obesity.
Compared to normal-weight controls, pre-surgical subjects had increased functional connectivity (FC) in the reward region (putamen) within the LH network, and increased FC in somatosensory cortical area (insula), as well as decreased FC in the cognitive control regions (prefrontal regions) within the MH network. After the surgery, post-surgical FC of the putamen within the LH network changed towards the patterns found in the control group. Furthermore, the changes in fasting glucose before and after the surgery were associated with the changes in FC of the putamen within the LH network.
The FC within the LH and MH networks were changed in subjects with obesity. Part of these altered FC was rescued after the surgery.
外侧下丘脑（LH）和内侧下丘脑（MH）在能量平衡中发挥重要作用。肥胖人群的下丘脑功能发生改变。然而，减重手术对这两个亚区功能的影响还研究甚少。
纳入 38 例肥胖受试者和 34 名年龄和性别匹配的正常体重对照者。其中 17 名肥胖受试者接受了腹腔镜袖状胃切除术。收集功能磁共振成像数据和代谢参数，以研究肥胖受试者两个下丘脑亚区的功能连接网络，以及袖状胃切除术对两个网络的影响。
与正常体重对照组相比，术前肥胖受试者 LH 网络中的奖励区域（壳核）的功能连接（FC）增加，MH 网络中的躯体感觉皮质区（岛叶）的 FC 增加，认知控制区域（前额叶区域）的 FC 减少。术后，LH 网络中的壳核的术后 FC 向对照组的模式转变。此外，手术前后空腹血糖的变化与 LH 网络中壳核的 FC 变化相关。
肥胖人群的 LH 和 MH 网络的 FC 发生改变。部分改变的 FC 在手术后得到恢复。
