Biological Anthropology Department, Medical Research Division, National Research Centre, Cairo, Egypt.
Pediatrics Department, Cairo University, Cairo, Egypt.
J Paediatr Child Health. 2019 Nov;55(11):1344-1350. doi: 10.1111/jpc.14419. Epub 2019 Mar 20.
Obesity and its metabolic complications are increasing in childhood and extend to adulthood. The aims of this study were to assess the prevalence of metabolic syndrome (MS) in a sample of Egyptian adolescent girls and investigate its association with apolipoprotein E.
A cross-sectional study design was used, including 200 Egyptian adolescent girls aged between 12 and 18 years. They were subjected to blood pressure (BP) measurement, anthropometric measurements (weight, height and waist circumference (WC)), laboratory investigations (fasting glucose and lipid profile) and molecular analysis (Apo E).
Overweight/obese girls were suffering significantly, more than normal-weight girls, from hypertension (66.7 vs. 40.8%), diabetes diagnosed by elevated fasting blood glucose (46.7 vs. 31.2%) and low high-density lipoprotein (HDL) (64 vs. 59.2%). Girls with MS had significantly higher values of body mass index Z-score, WC, BP, cholesterol and triglycerides and significantly lower HDL. Allele E3 (59.1 vs. 55.1%) was more frequent among girls with MS, while allele E4 (41 vs. 36.4) was more frequent among girls without MS. MS was the most prominent among girls with the E3/E4 genotype (35.7%), who had the highest frequency of elevated cholesterol, triglycerides, low-density lipoprotein and blood glucose, while girls with the E2/E4 genotype, which was rare among both groups, had the highest frequency of elevated BP (68.8%) and low HDL (71.4%).
MS was significantly more prominent among overweight/obese adolescent girls with the E3/E4 genotype, who had the highest frequency of disturbed lipid profile and blood glucose.
肥胖及其代谢并发症在儿童期和成年期都在增加。本研究旨在评估埃及青春期女孩中代谢综合征（MS）的患病率，并探讨其与载脂蛋白 E 的关系。
采用横断面研究设计，纳入 200 名年龄在 12 至 18 岁之间的埃及青春期女孩。对她们进行血压（BP）测量、人体测量学测量（体重、身高和腰围（WC））、实验室检查（空腹血糖和血脂谱）和分子分析（载脂蛋白 E）。
超重/肥胖女孩比正常体重女孩更易患高血压（66.7%对 40.8%）、空腹血糖升高导致的糖尿病（46.7%对 31.2%）和低高密度脂蛋白（HDL）（64%对 59.2%）。患有 MS 的女孩的体重指数 Z 评分、WC、BP、胆固醇和甘油三酯显著升高，HDL 显著降低。MS 女孩的等位基因 E3（59.1%对 55.1%）更常见，而等位基因 E4（41%对 36.4%）在无 MS 女孩中更常见。E3/E4 基因型的女孩 MS 最为突出（35.7%），她们的胆固醇、甘油三酯、低密度脂蛋白和血糖升高的频率最高，而 E2/E4 基因型的女孩在两组中都很少见，BP 升高的频率最高（68.8%），HDL 降低的频率最高（71.4%）。
超重/肥胖的青春期女孩中，E3/E4 基因型的 MS 更为突出，她们的血脂和血糖紊乱频率最高。
