α-甲基赖氨酸对大肠杆菌和球形芽孢杆菌中L-赖氨酸摄取的抑制作用。

Inhibition of L-lysine uptake by alpha-methyl lysine in Escherichia coli and Bacillus sphaericus.

作者信息

Regenstreif C A, Kelland J G, Pansare S V, Vederas J C, Pickard M A

出版信息

Can J Microbiol. 1986 Jun;32(6):522-4. doi: 10.1139/m86-095.

Abstract

alpha-Methyl lysine was investigated as a potential inhibitor of lysine transport in Escherichia coli and Bacillus sphaericus. At equimolar concentrations, no inhibition was observed in either organism, but at 10X and 100X the lysine concentration, alpha-methyl lysine caused a 20-50% reduction in the initial rate of lysine uptake in both bacteria. A similar inhibitory effect was observed with epsilon-N-methyl lysine on lysine uptake in B. sphaericus, but not in E. coli. alpha-Methyl lysine had a reduced effect on ornithine uptake and no effect on arginine transport in either bacterium.

摘要

对α-甲基赖氨酸作为大肠杆菌和球形芽孢杆菌中赖氨酸转运潜在抑制剂进行了研究。在等摩尔浓度下，在这两种微生物中均未观察到抑制作用，但在赖氨酸浓度为10倍和100倍时，α-甲基赖氨酸使两种细菌中赖氨酸摄取的初始速率降低了20 - 50%。在球形芽孢杆菌中观察到ε-N-甲基赖氨酸对赖氨酸摄取有类似的抑制作用，但在大肠杆菌中未观察到。α-甲基赖氨酸对鸟氨酸摄取的影响较小，对两种细菌中的精氨酸转运均无影响。