Jang Won Jun, Song Seung Min, Park Yeji, Yun Jaesook
Department of Chemistry , Sungkyunkwan University , Suwon 16419 , Korea.
J Org Chem. 2019 Apr 5;84(7):4429-4434. doi: 10.1021/acs.joc.8b03045. Epub 2019 Mar 21.
We report a copper-catalyzed enantioselective hydroboration of α,β-unsaturated aldehydes with pinacolborane. α,β-Unsaturated aldehydes were converted to the corresponding γ-pinacolboronate alcohols in good yields and enantioselectivities through consecutive hydroboration of the C═O and C═C bonds. This process provides simple access to the hydroborated product of allylic alcohols, and the resulting γ-pinacolboronate alcohols could be utilized in various transformations.
我们报道了一种铜催化的α,β-不饱和醛与频哪醇硼烷的对映选择性硼氢化反应。通过C═O和C═C键的连续硼氢化反应，α,β-不饱和醛以良好的产率和对映选择性转化为相应的γ-频哪醇硼酸酯醇。该过程为烯丙醇的硼氢化产物提供了简便的合成途径，并且所得的γ-频哪醇硼酸酯醇可用于各种转化反应。
