Sakiyama H, Yasukawa M, Terasima T, Kanegasaki S
Cancer Res. 1986 Aug;46(8):3862-5.
Oncogenic transformation of mouse 10T 1/2 fibroblasts induced upon exposure to X-ray or N-methyl-N'-nitro-N-nitrosoguanidine was suppressed if lipopolysaccharide (LPS) was present in the culture medium. The suppressive effect of LPS was exerted within 24 h after irradiation. Suppression was dependent on the concentration of LPS added and LPS (2 micrograms/ml) derived from Salmonella minnesota R595 reduced the number of transformed type III foci per dish from 0.39 to 0.15. Indomethacin (1 to 30 microM) further enhanced the effect of LPS in a dose-dependent manner.
如果培养基中存在脂多糖（LPS），暴露于X射线或N-甲基-N'-硝基-N-亚硝基胍后诱导的小鼠10T 1/2成纤维细胞的致癌转化会受到抑制。LPS的抑制作用在照射后24小时内发挥。抑制作用取决于所添加LPS的浓度，来自明尼苏达沙门氏菌R595的LPS（2微克/毫升）可使每培养皿中转化的III型集落数量从0.39减少到0.15。吲哚美辛（1至30微摩尔）以剂量依赖的方式进一步增强了LPS的作用。
