过敏性疾病与癌症之间的关联：文献系统综述

The association between allergic diseases and cancer: a systematic review of the literature.

作者信息

Karim A F, Westenberg L E H, Eurelings L E M, Otten R, Gerth van Wijk R

机构信息

Department of Internal Medicine, Section Allergy and Clinical Immunology, Erasmus Medical Center Rotterdam, the Netherlands.

出版信息

Neth J Med. 2019 Feb;77(2):42-66.

PMID:30895928

Abstract

INTRODUCTION

Atopic syndrome (allergic rhinitis, asthma and eczema) and food allergies are frequently reported, especially in developed countries. Studies have previously suggested an inverse association between allergic diseases and cancer. The aim of this study was to investigate the association between allergic diseases and different types of cancers by performing a systematic review of the literature.

METHODS

A systematic literature search of Ovid Medline, Embase, Web of Science, Cochrane Library and Google Scholar was performed for studies on the association between allergic diseases and cancers.

RESULTS

We identified a total of 5868 articles through our search, with 145 articles describing an association between allergic diseases and cancers. Allergies were associated with reduced risk of brain cancer, pancreatic cancer and melanoma and with possibly reduced risk of lymphatic and hematopoietic cancer, colorectal cancer, urogenital cancers of women and cancers in general. Asthma, but not atopy without asthma, was however associated with increased risk of lung cancer. There is possibly no association between allergic diseases and the risk of breast cancer and prostate cancer.

CONCLUSION

Overall, allergic diseases are inversely associated with the risk of cancers.

摘要

引言

特应性综合征（过敏性鼻炎、哮喘和湿疹）以及食物过敏的报道屡见不鲜，尤其是在发达国家。此前的研究表明过敏性疾病与癌症之间存在负相关。本研究的目的是通过对文献进行系统综述，调查过敏性疾病与不同类型癌症之间的关联。

方法

对Ovid Medline、Embase、科学网、Cochrane图书馆和谷歌学术进行系统的文献检索，以查找关于过敏性疾病与癌症之间关联的研究。

结果

通过检索我们共识别出5868篇文章，其中145篇描述了过敏性疾病与癌症之间的关联。过敏与患脑癌、胰腺癌和黑色素瘤风险降低有关，并且可能与患淋巴和造血系统癌症、结直肠癌、女性泌尿生殖系统癌症及总体癌症风险降低有关。然而，哮喘（而非无哮喘的特应性）与患肺癌风险增加有关。过敏性疾病与患乳腺癌和前列腺癌风险之间可能不存在关联。