B.C. Centre on Substance Use, Vancouver, Canada.
Department of Medicine, University of British Columbia, Vancouver, Canada.
Drug Alcohol Rev. 2019 May;38(4):428-434. doi: 10.1111/dar.12921. Epub 2019 Mar 21.
While much research has sought to identify the factors associated with initiation and cessation of various forms of drug use among vulnerable youth, little is known about relapse into drug use in this population. We sought to characterise relapse into stimulant and opioid use among street-involved youth in Vancouver, Canada.
Data were collected between 2005 and 2017 from the At-Risk Youth Study, a prospective cohort study of street-involved youth who use illicit drugs in Vancouver. Multivariable extended Cox regression was utilised to identify factors associated with relapse into illegal stimulants and/or opioids among youth who had previously ceased using stimulants and/or opioids for 6 months or longer.
Among 246 participants who reported a period of cessation lasting 6 months or longer, 165 (67.1%) relapsed at some point during study follow-up. Youth who were recently incarcerated (adjusted hazard ratio [AHR]: 1.46), homeless (AHR: 1.43), or had a history of daily stimulant use (AHR: 1.48) were significantly more likely to report relapse, while youth of who identified as white (AHR: 0.74) were significantly less likely to report relapse (all P < 0.05).
Relapse into stimulants and/or opioids was common among youth in our setting, and incarceration, homelessness, and daily stimulant use were found to be positively associated with relapse among youth. Findings suggest that increased access to youth housing supports and alternatives to the criminalisation of drug use may help to reduce the rates of relapse into stimulants and/or opioids in this population.
虽然有大量研究试图确定与易受伤害的青年开始和停止各种形式的药物使用相关的因素,但对于该人群中药物使用的复吸知之甚少。我们旨在描述加拿大温哥华街头青年中重新开始使用兴奋剂和阿片类药物的情况。
数据来自 2005 年至 2017 年的风险青年研究,这是一项对温哥华街头使用非法药物的青年进行的前瞻性队列研究。利用多变量扩展 Cox 回归来确定在停止使用兴奋剂和/或阿片类药物 6 个月或更长时间后重新开始非法兴奋剂和/或阿片类药物使用的青年中与复吸相关的因素。
在 246 名报告有 6 个月或更长时间的停药期的参与者中,有 165 名(67.1%)在研究随访期间的某个时间点复发。最近被监禁(调整后的危险比 [AHR]:1.46)、无家可归(AHR:1.43)或有每日使用兴奋剂史(AHR:1.48)的青年更有可能报告复吸,而自认为是白人的青年(AHR:0.74)报告复吸的可能性显著降低(均 P < 0.05)。
在我们的研究环境中,兴奋剂和/或阿片类药物的复吸很常见,监禁、无家可归和每日使用兴奋剂与青年复吸呈正相关。研究结果表明,增加青年住房支持和替代药物滥用刑事化的机会可能有助于降低该人群中兴奋剂和/或阿片类药物的复吸率。