钯催化的芳胺与炔烃的烯丙基化反应构建 C-N 键。
Palladium-catalyzed allylation of aminophenol with alkynes to construct C-N bonds.
机构信息
College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China.
出版信息
Org Biomol Chem. 2019 Apr 3;17(14):3545-3551. doi: 10.1039/c9ob00333a.
PMID:30896704
Abstract
A method for the allylic alkylation of aminophenol with alkynes was developed using a palladium-catalysed allylation reaction with 100% atom economy. A series of structurally diverse N-allylic substituted allylamines were synthesized in good yields with high chemo-, regio-, and stereoselectivities under mild conditions.
摘要
开发了一种钯催化的烯丙基化反应，以实现氨基酚与炔烃的烯丙基烷基化方法，具有 100%的原子经济性。在温和条件下，通过该方法可以高化学选择性、区域选择性和立体选择性地合成一系列结构多样的 N-烯丙基取代的烯丙胺，产率良好。
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