晚期肾细胞癌的化学免疫疗法：一例长期存活者辅助使用欧洲白蜡树提取物治疗的病例报告
Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts.
作者信息
Werthmann Paul G, Kindermann Lothar, Kienle Gunver S
机构信息
Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Freiburg im Breisgau, Germany,
Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany,
出版信息
Complement Med Res. 2019;26(4):276-279. doi: 10.1159/000496866. Epub 2019 Mar 20.
INTRODUCTION
Metastatic renal cell carcinoma has a poor prognosis. Treatment approaches with immunotherapy show promising results in subpopulations. Viscum album extracts - used as an adjunct to cancer treatment - have cytotoxic, apoptogenic, and immune-stimulating properties and show synergistic effects with chemotherapy agents.
CASE REPORT
A 51-year-old man was diagnosed with metastatic renal cell carcinoma of clear cell histology which was classified as pT3a, N1, M1, G3. Nephrectomy was performed, and the patient received chemoimmunotherapy (interferon-α2a, interleukin-2, fluorouracil, isotretinoin). Additionally, he received V. album extracts as intravenous infusions and subcutaneous injections. One year after surgery, the patient was in complete remission, which is ongoing 18 years after the initial diagnosis.
DISCUSSION
This case shows an extraordinarily long survival of a metastasized renal cell carcinoma patient under chemoimmunotherapy and fever-inducing V. album extracts. This combined treatment might have synergistically contributed to tumor remission and control. With regard to clinical relevance, further investigations are needed.
引言
转移性肾细胞癌预后较差。免疫疗法的治疗方法在亚群中显示出有前景的结果。白树提取物——用作癌症治疗的辅助药物——具有细胞毒性、诱导凋亡和免疫刺激特性，并与化疗药物显示出协同作用。
病例报告
一名51岁男性被诊断为透明细胞组织学的转移性肾细胞癌，分类为pT3a、N1、M1、G3。进行了肾切除术，患者接受了化学免疫疗法（干扰素-α2a、白细胞介素-2、氟尿嘧啶、异维甲酸）。此外，他接受了白树提取物的静脉输注和皮下注射。手术后一年，患者完全缓解，自初次诊断后已持续18年。
讨论
该病例显示了一名转移性肾细胞癌患者在化学免疫疗法和诱导发热的白树提取物治疗下异常长的生存期。这种联合治疗可能协同促进了肿瘤缓解和控制。关于临床相关性，还需要进一步研究。
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