• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

定义由质子辐照钍产生的 Ac 和其他同位素的加速器处理时间。

Defining Processing Times for Accelerator Produced Ac and Other Isotopes from Proton Irradiated Thorium.

机构信息

Isotope Production Laboratory, Collider-Accelerator Division, Brookhaven National Laboratory, Upton, NY 11973, USA.

Isotope and Fuel Cycle Technology Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.

出版信息

Molecules. 2019 Mar 20;24(6):1095. doi: 10.3390/molecules24061095.

DOI:10.3390/molecules24061095
PMID:30897722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6471325/
Abstract

During the purification of radioisotopes, decay periods or time dependent purification steps may be required to achieve a certain level of radiopurity in the final product. Actinum-225 (Ac-225), Silver-111 (Ag-111), Astatine-211 (At-211), Ruthenium-105 (Ru-105), and Rhodium-105 (Rh-105) are produced in a high energy proton irradiated thorium target. Experimentally measured cross sections, along with MCNP6-generated cross sections, were used to determine the quantities of Ac-225, Ag-111, At-211, Ru-105, Rh-105, and other co-produced radioactive impurities produced in a proton irradiated thorium target at Brookhaven Linac Isotope Producer (BLIP). Ac-225 and Ag-111 can be produced with high radiopurity by the proton irradiation of a thorium target at BLIP.

摘要

在放射性同位素的纯化过程中,可能需要半衰期或时间依赖的纯化步骤来达到最终产物的一定放射纯度。锕-225(Ac-225)、银-111(Ag-111)、砹-211(At-211)、钌-105(Ru-105)和铑-105(Rh-105)是在高能质子辐照的钍靶中产生的。实验测量的截面以及 MCNP6 生成的截面用于确定在布鲁克海文 Linac 同位素生产者(BLIP)的质子辐照钍靶中产生的 Ac-225、Ag-111、At-211、Ru-105、Rh-105 和其他共生产放射性杂质的数量。Ac-225 和 Ag-111 可以通过在 BLIP 用质子辐照钍靶来以高放射纯度生产。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/5772d617dcc1/molecules-24-01095-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/3eb03874c31b/molecules-24-01095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/b6285ef3afc9/molecules-24-01095-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/cbf8e0642561/molecules-24-01095-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/84681b74b604/molecules-24-01095-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/e6d2fdd9cce0/molecules-24-01095-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/5772d617dcc1/molecules-24-01095-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/3eb03874c31b/molecules-24-01095-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/b6285ef3afc9/molecules-24-01095-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/cbf8e0642561/molecules-24-01095-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/84681b74b604/molecules-24-01095-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/e6d2fdd9cce0/molecules-24-01095-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edc/6471325/5772d617dcc1/molecules-24-01095-g006.jpg

相似文献

1
Defining Processing Times for Accelerator Produced Ac and Other Isotopes from Proton Irradiated Thorium.定义由质子辐照钍产生的 Ac 和其他同位素的加速器处理时间。
Molecules. 2019 Mar 20;24(6):1095. doi: 10.3390/molecules24061095.
2
Chromatographic separation of the theranostic radionuclide Ag from a proton irradiated thorium matrix.从质子辐照的钍基体中色谱分离治疗放射性核素 Ag。
Anal Chim Acta. 2018 Jan 15;998:75-82. doi: 10.1016/j.aca.2017.10.020. Epub 2017 Oct 30.
3
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.离子交换和萃取色谱法在从质子辐照钍金属中分离锕用于分析目的方面的应用。
J Chromatogr A. 2015 Feb 6;1380:55-63. doi: 10.1016/j.chroma.2014.12.045. Epub 2014 Dec 18.
4
Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals.优化阳离子交换以分离锕-225 放射性钍、镭-223 和其他金属。
Molecules. 2019 May 18;24(10):1921. doi: 10.3390/molecules24101921.
5
Large scale accelerator production of Ac: Effective cross sections for 78-192MeV protons incident on Th targets.锕的大规模加速器生产:78 - 192兆电子伏特质子入射钍靶的有效截面
Appl Radiat Isot. 2016 Dec;118:366-374. doi: 10.1016/j.apradiso.2016.09.026. Epub 2016 Sep 28.
6
225Ac and 223Ra production via 800 MeV proton irradiation of natural thorium targets.通过用800兆电子伏特质子辐照天然钍靶产生225Ac和223Ra 。
Appl Radiat Isot. 2012 Nov;70(11):2590-5. doi: 10.1016/j.apradiso.2012.07.003. Epub 2012 Jul 10.
7
An alternative radiochemical separation strategy for isolation of Ac and Ra isotopes from high energy proton irradiated thorium targets for further application in Targeted Alpha Therapy (TAT).一种替代的放射性化学分离策略,用于从高能质子辐照的钍靶中分离 Ac 和 Ra 同位素,以进一步应用于靶向 alpha 治疗(TAT)。
Nucl Med Biol. 2022 Sep-Oct;112-113:35-43. doi: 10.1016/j.nucmedbio.2022.06.003. Epub 2022 Jun 17.
8
Construction of a thorium/actinium generator at the Canadian Nuclear Laboratories.在加拿大核实验室建造钍/锕发生器。
Appl Radiat Isot. 2020 Oct;164:109262. doi: 10.1016/j.apradiso.2020.109262. Epub 2020 Jun 15.
9
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV.低于200兆电子伏特时,质子在天然钍靶中诱发与产生225锕和223镭相关的截面。
Appl Radiat Isot. 2012 Nov;70(11):2602-7. doi: 10.1016/j.apradiso.2012.07.006. Epub 2012 Jul 11.
10
Production of Pa by proton irradiation of Th at the LANL isotope production facility: Precursor of U for targeted alpha therapy.在洛斯阿拉莫斯国家实验室同位素生产设施中通过对钍进行质子辐照生产镤:用于靶向α治疗的铀的前体。
Appl Radiat Isot. 2020 Feb;156:108973. doi: 10.1016/j.apradiso.2019.108973. Epub 2019 Nov 5.

引用本文的文献

1
Metal-Based Radiopharmaceuticals in Inorganic Chemistry.金属基放射性药物在无机化学中的应用。
Molecules. 2023 Mar 1;28(5):2290. doi: 10.3390/molecules28052290.
2
Radiopharmaceutical Quality Control Considerations for Accelerator-Produced Actinium Therapies.加速器生产锕系疗法用放射性药物的质量控制考虑因素。
Cancer Biother Radiopharm. 2022 Jun;37(5):355-363. doi: 10.1089/cbr.2022.0010.
3
Feasibility of a novel photoproduction of Ac and Th with natural thorium target.用天然钍靶进行新型光致生产 Ac 和 Th 的可行性。

本文引用的文献

1
Chromatographic separation of the theranostic radionuclide Ag from a proton irradiated thorium matrix.从质子辐照的钍基体中色谱分离治疗放射性核素 Ag。
Anal Chim Acta. 2018 Jan 15;998:75-82. doi: 10.1016/j.aca.2017.10.020. Epub 2017 Oct 30.
2
Consensus nomenclature rules for radiopharmaceutical chemistry - Setting the record straight.放射性药物化学的共识命名规则——澄清事实。
Nucl Med Biol. 2017 Dec;55:v-xi. doi: 10.1016/j.nucmedbio.2017.09.004. Epub 2017 Oct 2.
3
Large scale accelerator production of Ac: Effective cross sections for 78-192MeV protons incident on Th targets.
Sci Rep. 2022 Jan 10;12(1):372. doi: 10.1038/s41598-021-04339-9.
4
Alpha emitting nuclides for targeted therapy.用于靶向治疗的发射阿尔法粒子的核素。
Nucl Med Biol. 2021 Jan;92:228-240. doi: 10.1016/j.nucmedbio.2020.08.004. Epub 2020 Sep 1.
5
The application of poorly crystalline silicotitanate in production of Ac. poorly 晶硅酸钛在 Ac 生产中的应用。
Sci Rep. 2019 Aug 14;9(1):11808. doi: 10.1038/s41598-019-48021-7.
6
Optimization of Cation Exchange for the Separation of Actinium-225 from Radioactive Thorium, Radium-223 and Other Metals.优化阳离子交换以分离锕-225 放射性钍、镭-223 和其他金属。
Molecules. 2019 May 18;24(10):1921. doi: 10.3390/molecules24101921.
锕的大规模加速器生产:78 - 192兆电子伏特质子入射钍靶的有效截面
Appl Radiat Isot. 2016 Dec;118:366-374. doi: 10.1016/j.apradiso.2016.09.026. Epub 2016 Sep 28.
4
225Ac-PSMA-617 for PSMA-Targeted α-Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer.225Ac-PSMA-617用于转移性去势抵抗性前列腺癌的PSMA靶向α放射治疗。
J Nucl Med. 2016 Dec;57(12):1941-1944. doi: 10.2967/jnumed.116.178673. Epub 2016 Jul 7.
5
Application of ion exchange and extraction chromatography to the separation of actinium from proton-irradiated thorium metal for analytical purposes.离子交换和萃取色谱法在从质子辐照钍金属中分离锕用于分析目的方面的应用。
J Chromatogr A. 2015 Feb 6;1380:55-63. doi: 10.1016/j.chroma.2014.12.045. Epub 2014 Dec 18.
6
Bismuth-213 and actinium-225 -- generator performance and evolving therapeutic applications of two generator-derived alpha-emitting radioisotopes.铋 - 213和锕 - 225——两种基于发生器产生的α发射性放射性同位素的发生器性能及不断发展的治疗应用
Curr Radiopharm. 2012 Jul;5(3):221-7. doi: 10.2174/1874471011205030221.
7
Astatine-211: production and availability.砹-211:生产与可得性
Curr Radiopharm. 2011 Jul;4(3):177-85. doi: 10.2174/1874471011104030177.
8
Yield and purity of 82Sr produced via the natRb(p,xn) 82Sr process.
Appl Radiat Isot. 2007 Feb;65(2):247-52. doi: 10.1016/j.apradiso.2006.08.001. Epub 2006 Oct 4.
9
A new internal target system for production of (211)At on the cyclotron U-120M.一种用于在回旋加速器U - 120M上生产砹 - 211的新型内部靶系统。
Appl Radiat Isot. 2005 Jul;63(1):49-53. doi: 10.1016/j.apradiso.2005.02.006. Epub 2005 Apr 13.