Heise Ruth, Schmitt Laurenz, Huth Laura, Krings Laura, Kluwig David, Katsoulari Krista-Vasiliki, Steiner Timm, Hölzle Frank, Baron Jens Malte, Huth Sebastian
a Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen University , Aachen , Germany.
b Interdisciplinary Center for Laser Medicine, Medical Faculty, RWTH Aachen University , Aachen , Germany.
Cutan Ocul Toxicol. 2019 Sep;38(3):274-278. doi: 10.1080/15569527.2019.1597879. Epub 2019 Apr 20.
Laser therapy with an ablative CO laser is a prominent treatment option for photo-damaged skin. The healing process and therefore the success of a laser can be supported by an appropriate postoperative treatment of the laser-treated skin. : The effect of a dexpanthenol-containing ointment with petroleum jelly on wound healing after fractional ablative CO laser therapy of photo-damaged skin. A total of 38 patients with photo-damaged skin received fractional ablative CO laser treatment. Occlusive wound care was conducted for a period of 7 days. The complete wound area was divided into two sections: one that was treated with a dexpanthenol-containing ointment and a section that was treated with petroleum jelly. This study had three primary outcome measures: (1) Overview images as well as dermatoscopic images of the laser treated skin were taken immediately after laser treatment and on days 1, 2, 5 and 14 (study visits). Dermatoscopic images were analysed to determine changes of the diameter of the individual lesions between the study visits. (2) Wound-healing rate was visually assessed, based on the measure of re-epithelialization. (3) Cosmetic results were evaluated during study visits by patients and physicians applying a visual analogue scale (VAS). Measuring the diameter of laser-generated lesions revealed a significantly faster cure of the lesions in wound sections that were treated with the dexpanthenol-containing ointment on days 1 and 2, in comparison to the lesions that were treated with petroleum jelly. Concordantly, visual evaluation of the wounds revealed significantly better cosmetic results and re-epithelialization on days 1, 2 and 5 after laser treatment in wound sites that were treated with the dexpanthenol-containing ointment. All patients exhibited a completed wound healing on day 14 after laser treatment. In this comparative study, post-operative treatment of laser-treated skin with a dexpanthenol-containing ointment led to a significantly faster wound closure in comparison to petroleum jelly, especially during the early phase of wound healing. Moreover, assessment of the cosmetic result exhibited beneficial effects of the dexpanthenol-containing ointment in the post-operative wound care after laser treatment. These results emphasize that the use of a dexpanthenol-containing ointment in the post-operative phase following CO2 laser therapy could be a promising alternative to the routinely used treatment with petroleum jelly.
使用剥脱性CO激光进行激光治疗是光损伤皮肤的一种重要治疗选择。激光治疗后的皮肤进行适当的术后处理有助于愈合过程，进而提高激光治疗的成功率。：含泛醇凡士林软膏对光损伤皮肤剥脱性CO激光治疗后伤口愈合的影响。共有38例光损伤皮肤患者接受了剥脱性CO激光治疗。进行了为期7天的封闭伤口护理。将完整的伤口区域分为两部分：一部分用含泛醇的软膏治疗，另一部分用凡士林治疗。本研究有三个主要观察指标：（1）在激光治疗后即刻以及第1、2、5和14天（研究访视）拍摄激光治疗皮肤的概览图像和皮肤镜图像。分析皮肤镜图像以确定各病变直径在研究访视之间的变化。（2）根据再上皮化程度，通过视觉评估伤口愈合率。（3）在研究访视期间，患者和医生使用视觉模拟量表（VAS）评估美容效果。测量激光产生的病变直径发现，与用凡士林治疗的病变相比，在第1天和第2天，用含泛醇软膏治疗的伤口部位的病变愈合明显更快。与此一致的是，对伤口的视觉评估显示，在激光治疗后第1、2和5天，用含泛醇软膏治疗的伤口部位的美容效果和再上皮化明显更好。所有患者在激光治疗后第14天伤口完全愈合。在这项比较研究中，与凡士林相比，用含泛醇的软膏对激光治疗后的皮肤进行术后处理可显著加快伤口闭合，尤其是在伤口愈合的早期阶段。此外，美容效果评估显示含泛醇软膏在激光治疗后的术后伤口护理中具有有益作用。这些结果强调，在CO2激光治疗后的术后阶段使用含泛醇的软膏可能是常规使用凡士林治疗的一种有前景的替代方法。
