Chang Yunyoung C, Croix Jennifer, Hernandez Shannon, Chapas Anne
J Drugs Dermatol. 2018 Nov 1;17(11):1178 - 1182.
Purpose: Fractionated carbon dioxide (CO2) laser resurfacing uses fractional photothermolysis with an ablative 10,600-nm wavelength for treatment of rhytides and photodamage. Although associated with reduced side effect profile from traditional ablative lasers, fractionated lasers can lead to significant erythema, edema, crusting, and exudation for 14 days. Post-care includes regular distilled water soaks and healing ointment. This study evaluated efficacy and patient satisfaction of a novel plant-based hypoallergenic ointment (Doctor Rogers RESTORE®Healing Balm; Product 1) compared to petroleum-based lanolin-containing ointment (Aquaphor® Healing Ointment; Product 2) to accelerate wound healing post-laser resurfacing of the face. Design: This was a single-center, prospective randomized, double-blinded, split-face comparative study of 10 subjects with photo-aging and rhytids who received treatment with fractionated CO2 laser between September 2017 and January 2018. Product 1 and Product 2 were randomized to each half of the face and applied from days 0 to 7 with an option to continue to day 14. The primary outcome measures were Investigator-rated degree of erythema, edema, crusting, exudation, and percentage healing, with follow-up evaluations performed at days 2, 4, 7, 14, and 30. The secondary outcome measure was patient satisfaction. Summary: Based on investigator post-resurfacing scores, day 4 showed improved erythema (50%), edema (50%), crusting (40%), and percentage healing (60%) on the Product 1-treated side compared to Product 2, with the majority of remaining patients scoring the same as Product 2. On day 14, Product 1 demonstrated improvement in erythema (50%), edema (30%), and percentage healing (30%) compared to Product 2, with all remaining patients scoring the same as Product 2. Crusting was the same between the two products on day 14. Ninety percent of patients preferred Product 1 over Product 2, found it easier to use, and were more likely to use it in the future. Conclusion: Product 1 is a plant-based hypoallergenic ointment that is safe and effective post-laser treatment and is associated with high patient satisfaction and preference.
分次二氧化碳（CO2）激光皮肤磨削术采用波长为10600纳米的剥脱性光热分解技术来治疗皱纹和光损伤。尽管与传统剥脱性激光相比，分次激光的副作用有所减少，但仍会导致长达14天的明显红斑、水肿、结痂和渗出。术后护理包括定期用蒸馏水浸泡和涂抹愈合软膏。本研究评估了一种新型植物基低敏软膏（罗杰斯医生修复愈合膏；产品1）与含凡士林羊毛脂软膏（优色林愈合软膏；产品2）相比，在加速面部激光皮肤磨削术后伤口愈合方面的疗效和患者满意度。
这是一项单中心、前瞻性随机、双盲、半脸对照研究，研究对象为10名有光老化和皱纹的受试者，于2017年9月至2018年1月接受分次CO2激光治疗。产品1和产品2随机应用于半脸，从第0天至第7天使用，也可选择持续至第14天。主要观察指标为研究者评定的红斑、水肿、结痂、渗出程度和愈合百分比，在第2、4、7、14和30天进行随访评估。次要观察指标为患者满意度。
根据研究者术后评分，与产品2相比，在产品1治疗侧，第4天时红斑（改善50%）、水肿（改善50%）、结痂（改善40%）和愈合百分比（改善60%）均有改善，其余大多数患者评分与产品2相同。在第14天时，与产品2相比，产品1在红斑（改善50%）、水肿（改善30%）和愈合百分比（改善30%）方面表现出改善，其余所有患者评分与产品2相同。第14天时，两种产品的结痂情况相同。90%的患者更喜欢产品1而非产品2，认为其使用更方便，且未来更有可能使用。
产品1是一种植物基低敏软膏，激光治疗后安全有效，患者满意度高且更受青睐。
