a WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine , The University of Hong Kong , Hong Kong , Hong Kong SAR, People's Republic of China.
b Department of Veterinary Public Health and Pharmacology, Faculty of Veterinary Medicine and Animal Science , University of Peradeniya , Peradeniya , Sri Lanka.
Emerg Microbes Infect. 2019;8(1):404-412. doi: 10.1080/22221751.2019.1572433.
Haemagglutination inhibition (HAI) antibody titres are a correlate of protection for influenza virus infection, but several studies have also demonstrated the protective role of anti-neuraminidase (anti-NA) antibodies. However, there is limited data on anti-NA antibody responses in naturally occurring human influenza. We investigated anti-NA antibody responses to pandemic N1 and seasonal N1 in 18 RT-PCR-confirmed patients with naturally acquired pandemic influenza A (H1N1) 2009 disease detected as part of a prospective community study of influenza. There were increases in neuraminidase inhibition (NAI) antibody titres to both pandemic and seasonal N1 antigens, with greater fold increases in those who had low levels of anti-pandemic N1 titres in acute sera. Of 18 patients with pandemic H1N1 infection, fourfold increases in antibody were observed by HAI in 11 (61%) patients, by anti-pandemic N1 inhibition in 13 (72%) or either in 15 of them (83%). Prior seasonal H1N1 virus infections had elicited cross-reactive anti-pandemic N1 antibody titres in some people prior to the emergence of the 2009 pandemic H1N1 virus. Antibody responses to the anti-N1 pandemic 2009 virus and cross-reactive responses to anti-seasonal N1 antibody were seen in influenza A pandemic 2009 infections. NAI antibodies can complement HAI antibody in sero-diagnosis and sero-epidemiology.
血凝抑制（HAI）抗体滴度是流感病毒感染的保护相关因素，但几项研究也表明抗神经氨酸酶（抗-NA）抗体具有保护作用。然而，关于自然发生的人类流感中抗-NA 抗体反应的数据有限。我们研究了 18 例经 RT-PCR 确认为自然获得性 2009 年甲型 H1N1 大流行流感的患者的抗-NA 抗体反应，这些患者是流感前瞻性社区研究的一部分。在急性血清中抗大流行 N1 滴度较低的患者中，神经氨酸酶抑制（NAI）抗体滴度对大流行和季节性 N1 抗原均增加，且倍数增加更大。在 18 例大流行 H1N1 感染患者中，通过 HAI 在 11 例（61%）患者中、通过抗大流行 N1 抑制在 13 例（72%）或其中 15 例（83%）观察到抗体的 4 倍增加。在 2009 年大流行 H1N1 病毒出现之前，一些人先前的季节性 H1N1 病毒感染已经引起了针对大流行 N1 的交叉反应性抗体滴度。在 2009 年大流行流感感染中观察到了针对抗-N1 大流行 2009 病毒的抗体反应和针对交叉反应性抗季节性 N1 抗体的反应。NAI 抗体可补充 HAI 抗体在血清学诊断和血清流行病学中的作用。
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