Department of Paediatric Surgery, Meyer Children's Hospital, Florence, Italy.
Department of Paediatric Surgery, Royal Manchester Children's Hospital, Meyer, United Kingdom.
J Pediatr Surg. 2019 Jun;54(6):1214-1219. doi: 10.1016/j.jpedsurg.2019.02.031. Epub 2019 Feb 28.
Total esophagogastric dissociation (TEGD) has been performed in our institution since 1994, predating its published description by Bianchi in 1997. Originally it was considered a rescue procedure when conventional antireflux surgery failed. Recently TEGD has been considered a viable primary option for the treatment of gastroesophageal reflux disease (GERD) in severely neurological impaired (NI) patients. We describe our institution's experience of TEGD in this selected cohort of patients.
An institutional retrospective review was performed detailing our total experience of open TEGD between 1994 and 2015 in severely neurologically impaired (NI) patients. Demographic, complications, and outcome were analyzed.
Sixty-six NI patients underwent TEGD between 1994 and 2015 (39 female). Primary TEGD was performed in forty-nine patients (74.2%), while the remainder were rescue procedures following the failure of previous antireflux surgery. In 98% of cases no recurrence of clinically significant reflux was reported. The mean hospital length of stay was 10.2 days. There were sixteen reported complications in twelve patients representing 18.2% of the cohort. One death was attributable to the procedure (1.5%). Median follow-up was 31.6 months (range, 1.3-137.9 months).
TEGD appears to be a valid surgical option to treat severe GERD in severely neurologically impaired children, both as a primary procedure and as a rescue procedure following failure of anti-reflux surgery. Further studies comparing TEGD versus laparoscopic fundoplication are desirable to understand which of these procedures can be the most effective in this compromised group of patients.
Retrospective study Level of evidence: IV.
自 1994 年以来,我院一直在开展全胃食管分离术(TEGD),早于 Bianchi 于 1997 年发表的描述。最初,它被认为是传统抗反流手术失败时的一种抢救措施。最近,TEGD 被认为是治疗严重神经损伤(NI)患者胃食管反流病(GERD)的一种可行的主要选择。我们描述了我们机构在这一选定的患者群体中进行 TEGD 的经验。
对机构进行了回顾性分析,详细介绍了我们在 1994 年至 2015 年期间对严重神经损伤(NI)患者进行的开放性 TEGD 的全部经验。分析了人口统计学、并发症和结果。
1994 年至 2015 年期间,66 名 NI 患者接受了 TEGD(39 名女性)。49 名患者(74.2%)进行了原发性 TEGD,其余患者为先前抗反流手术后失败的挽救性手术。98%的病例报告无临床显著反流复发。平均住院时间为 10.2 天。12 名患者中有 16 例报告有并发症,占队列的 18.2%。1 例死亡归因于该手术(1.5%)。中位随访时间为 31.6 个月(范围,1.3-137.9 个月)。
TEGD 似乎是治疗严重神经损伤儿童严重 GERD 的有效手术选择,无论是作为原发性手术还是抗反流手术后失败的挽救性手术。为了了解这些手术在这组受损患者中哪一种最有效,需要进一步比较 TEGD 与腹腔镜胃底折叠术的研究。
回顾性研究 证据等级:IV 级。