Aisaka K, Ando S, Kokubo K, Yoshida K, Mori H
Nihon Naibunpi Gakkai Zasshi. 1986 May 20;62(5):662-71. doi: 10.1507/endocrine1927.62.5_662.
The changes in serum prolactin levels during the menstrual cycle have not been clarified yet. The present study was conducted to investigate whether the changes in serum prolactin levels during the menstrual cycle exist in ovulatory infertile patients having high prolactin release due to TRH administration described below (transient hyperprolactinemia) and control cases. Serum prolactin levels in both groups were less than 25 ng/ml at daytime. In the patients with transient hyperprolactinemia, serum prolactin levels showed more than 150 ng/ml at 30 min. after the administration of 500 micrograms of TRH, and those were less than 150 ng/ml in the normal control group. The daily changes of serum FSH, LH, prolactin, estradiol and progesterone levels were determined by radioimmunoassay in 6 cases of transient hyperprolactinemia and 5 controls which showed normal ovulatory cycles in the patterns of the BBT charts and other hormones. An estrogen feedback test was also carried out at the mid-luteal phase in 9 cases of transient hyperprolactinemia and the controls to determine serum levels of FSH, LH, prolactin and estradiol. In the patients with transient hyperprolactinemia, 5 mg of bromocriptine was administered every day for more than 30 days, and the effects of bromocriptine on the changes in serum gonadotropin levels by the estrogen feedback test were also analysed. Serum prolactin levels in the follicular, ovulatory and mid-luteal phases increased significantly in the patients with transient hyperprolactinemia, compared to the controls (p less than 0.005). The pattern of serum prolactin levels in the patients with transient hyperprolactinemia was almost synchronized with that of serum estradiol levels. There was also a significant correlation (r = 0.5782, p less than 0.005) between the prolactin and estradiol levels in the serum of the patients. The obvious change was not noted in serum prolactin levels during the menstrual cycle of the controls. No significant change in other hormones was observed during the cycle between these two groups. After the administration of estradiol benzoate (100 micrograms/kg), serum estradiol levels increased markedly, serum prolactin levels increased with the similar change in serum estradiol levels, and serum prolactin levels in the patients with transient hyperprolactinemia were significantly higher compared to those of the controls (p less than 0.01 approximately 0.005). The responses of serum gonadotropin levels by the administration of estradiol benzoate had good positive and negative feedback effects in the patients with transient hyperprolactinemia as well as those of the control group.(ABSTRACT TRUNCATED AT 400 WORDS)
月经周期中血清催乳素水平的变化尚未明确。本研究旨在调查在如下所述因促甲状腺激素释放激素（TRH）给药导致催乳素释放增加（短暂性高催乳素血症）的排卵性不孕患者及对照病例中，月经周期中血清催乳素水平是否存在变化。两组患者白天的血清催乳素水平均低于25 ng/ml。在短暂性高催乳素血症患者中，静脉注射500微克TRH后30分钟，血清催乳素水平超过150 ng/ml，而正常对照组则低于150 ng/ml。采用放射免疫分析法测定了6例短暂性高催乳素血症患者和5例对照者（其基础体温图及其他激素显示排卵周期正常）血清促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素、雌二醇和孕酮水平的每日变化。在9例短暂性高催乳素血症患者及对照者的黄体中期还进行了雌激素反馈试验，以测定血清FSH、LH、催乳素和雌二醇水平。在短暂性高催乳素血症患者中，每天给予5毫克溴隐亭，疗程超过30天，并分析溴隐亭对雌激素反馈试验中血清促性腺激素水平变化的影响。与对照组相比，短暂性高催乳素血症患者在卵泡期、排卵期和黄体中期的血清催乳素水平显著升高（p<0.005）。短暂性高催乳素血症患者血清催乳素水平的变化模式与血清雌二醇水平几乎同步。患者血清中催乳素与雌二醇水平之间也存在显著相关性（r = 0.5782，p<0.005）。对照组月经周期中血清催乳素水平未观察到明显变化。两组间其他激素在周期中未观察到显著变化。注射苯甲酸雌二醇（100微克/千克）后，血清雌二醇水平显著升高，血清催乳素水平随血清雌二醇水平的类似变化而升高，短暂性高催乳素血症患者的血清催乳素水平显著高于对照组（p<0.01至0.005）。在短暂性高催乳素血症患者以及对照组中，注射苯甲酸雌二醇后血清促性腺激素水平的反应均具有良好的正负反馈效应。（摘要截选至400字）
