Furuhjelm M, Rydner T, Carlström K
Acta Obstet Gynecol Scand. 1980;59(2):137-41. doi: 10.3109/00016348009154630.
Of 17 patients with longstanding (3--15 years, mean 7.7 years) amenorrhea and hyperprolactinemia, 8 developed their amenorrhea after the use of oral contraceptives (Group I) and 9 became amenorrhoic spontaneously (Group II). There were no differences between the groups with respect to the basal serum levels of FSH, LH, low polar estrogens (estradiol-17 beta + estrone) and prolactin. Tomography revealed pituitary adenoma in four patients. One of these developed symptoms of her tumor during pregnancy; the symptoms disappeared after delivery. The other patients with tumors are checked twice a year and have not yet received any treatment. The patients with no detectable tumors were treated with bromocriptine starting with 1.25 X 3 daily. The peripheral serum levels of prolactin, FSH, LH, low polar estrogens and progesterone were determined once a week and if the prolactin levels remained high, the bromocriptine dose was increased. All these patients started to menstruate as soon as prolactin returned to normal levels (below 25 micrograms/l). All patients who wished to became pregnant, i.e. 6 patients. Three were delivered by cesarean section, one had a normal delivery and two are still pregnant. There was no difference between Group I and Group II in the dose required or in the duration of treatment before menstruation started. Three cases of galactorrhea were found.
在17例患有长期（3 - 15年，平均7.7年）闭经和高催乳素血症的患者中，8例在使用口服避孕药后出现闭经（第一组），9例自发闭经（第二组）。两组在促卵泡生成素（FSH）、促黄体生成素（LH）、低极性雌激素（雌二醇 - 17β + 雌酮）和催乳素的基础血清水平方面没有差异。断层扫描显示4例患者有垂体腺瘤。其中1例在怀孕期间出现肿瘤症状；产后症状消失。其他患有肿瘤的患者每年检查两次，尚未接受任何治疗。未检测到肿瘤的患者从每天1.25毫克，分3次服用开始使用溴隐亭治疗。每周测定一次外周血清中催乳素、FSH、LH、低极性雌激素和孕酮的水平，如果催乳素水平仍然很高，则增加溴隐亭剂量。一旦催乳素恢复到正常水平（低于25微克/升），所有这些患者都开始月经来潮。所有希望怀孕的患者，即6例。3例剖宫产分娩，1例顺产，2例仍在怀孕。第一组和第二组在开始月经前所需剂量或治疗持续时间方面没有差异。发现3例溢乳。
