Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
J Microbiol Methods. 2019 May;160:130-142. doi: 10.1016/j.mimet.2019.03.017. Epub 2019 Mar 18.
This review article is an updated overview on lipid-polymer hybrid nanoparticles (LPHNs) including the various types of LPHNs polymers used in their preparation, various methods of preparation, their physiochemical, in-vitro and in-vivo evaluation parameters and their application in various delivery systems. LPHNs show a combined advantage of biodegradable polymeric nanoparticles and liposomes. LPHNs mainly consist of a biodegradable polymeric material core containing drugs or any substances which are to be encapsulated then this core is further enclosed by a phospholipid layer i.e. lipid PEG layer. LPHNs show good physical strength and biocompatibility. The hybrid structural design can offer various benefits such as controlled particle size, high drug loading, surface functionality with various ligands (antibody fragments, peptides, monoclonal antibodies, aptamers, and folate molecules), and encapsulation of combinational therapeutic agents, showing prolonged release of drug and drug circulates in the blood for longer duration. Significantly, the LPHNs have recently been confirmed as a better drug delivery route and good cellular delivery efficacy of various drugs as compared to polymeric nanoparticles and liposomes.
这篇综述文章是对脂质-聚合物杂化纳米粒（LPHN）的更新概述，包括用于其制备的各种类型的 LPHN 聚合物、各种制备方法、它们的物理化学、体外和体内评价参数以及它们在各种递药系统中的应用。LPHN 显示出可生物降解聚合物纳米粒和脂质体的综合优势。LPHN 主要由含有药物或任何待包封物质的可生物降解聚合物材料核心组成，然后将该核心进一步用磷脂层（即脂质 PEG 层）封闭。LPHN 具有良好的物理强度和生物相容性。杂化结构设计可以提供多种益处，例如控制粒径、高载药量、具有各种配体（抗体片段、肽、单克隆抗体、适体和叶酸分子）的表面功能以及包封组合治疗剂，从而实现药物的延长释放和药物在血液中更长时间的循环。重要的是，与聚合物纳米粒和脂质体相比，LPHN 最近已被证实为更好的药物递药途径和各种药物的良好细胞递药效果。
