Hashemzadeh Bayram, Idani Esmaeil, Goudarzi Gholamreza, Ankali Kambiz Ahmadi, Sakhvidi Mohammad Javad Zare, Akbar Babaei Ali, Hashemzadeh Hassan, Vosoughi Mehdi, Mohammadi Mohammad Javad, Neisi Abdolkazem
Department of Environmental Health Engineering, Health Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Environmental Health, Khoy School of Nursing, Urmia University of Medical Sciences, Urmia, Iran.
Saudi J Biol Sci. 2019 Mar;26(3):473-480. doi: 10.1016/j.sjbs.2016.11.008. Epub 2016 Nov 12.
The aim of this study was to determine the correlation between PM and NO pollutants and oxidative stress marker (8-isoprostane) and lung function tests (FVC and FEV) in healthy children who were living and studying in three different areas of Ahvaz city including A: Naderi site with high traffic, A: Alavi Alley site with average traffic, and A: Ein 2 site with low traffic (a rural area on the suburb of Ahvaz). 30 students in the 12-13 year-old range were selected from each studied zone (1, 2 and 3 sites) during three months of year. Of each student, one sample was taken every two weeks to measure 8-isoprostane of exhaled breath condensate (EBC). Air pollution data were collected from three air quality monitoring stations. Also, the relationship between air pollution and 8-isoprostane as well as lung function tests were determined using generalized estimating equations (GEE). The mean concentration of PM and NO in A, A and A areas were 116, 92 and 45 (μg/m) also 77, 53 and 14 (ppb) respectively. Among all studied students, there was a significant correlation between the increase of mean concentration of PM and NO in 1-4 before sampling day, increased 8-isoprostane concentration and decreased FEV, while there was no significant correlation between them and decreased FVC. In A site, an increase in IQR (13 μg/m) PM and IQR (6.5 ppb) NO on 1-4 days before sampling was associated with 0.38 unit (95% CI: 0.11, 0.65) and 1.1 unit (95% CI: 0.85, 1.35) increase in 8-isoprostane concentration, also decreased 121 ml and 190 ml FEV, respectively. Results showed that the short-term exposure to traffic-related air pollution can decrease the values of lung function indices and increase the oxidative stress. It may adversely affect children's lungs.
本研究的目的是确定在阿瓦士市三个不同区域生活和学习的健康儿童中，颗粒物（PM）和一氧化氮（NO）污染物与氧化应激标志物（8-异前列腺素）以及肺功能测试（用力肺活量（FVC）和第一秒用力呼气容积（FEV））之间的相关性。这三个区域分别为：A：交通流量大的纳迪里地区；A：交通流量中等的阿拉维胡同地区；A：交通流量小的艾因2地区（阿瓦士市郊的一个农村地区）。在一年中的三个月里，从每个研究区域（1、2和3号地点）选取30名年龄在12 - 13岁的学生。每隔两周采集每个学生的一份样本，以测量呼出气冷凝物（EBC）中的8-异前列腺素。空气污染数据从三个空气质量监测站收集。此外，使用广义估计方程（GEE）确定空气污染与8-异前列腺素以及肺功能测试之间的关系。A、A和A区域中PM和NO的平均浓度分别为116、92和45（μg/m），以及77、53和14（ppb）。在所有研究的学生中，采样日前1 - 4天PM和NO平均浓度的增加、8-异前列腺素浓度的增加与FEV的降低之间存在显著相关性，而它们与FVC的降低之间无显著相关性。在A地点，采样前1 - 4天四分位距（IQR）（13 μg/m）的PM增加和IQR（6.5 ppb）的NO增加分别与8-异前列腺素浓度增加0.38个单位（95%置信区间：0.11，0.65）和1.1个单位（95%置信区间：0.85，1.35）相关，同时FEV分别降低121 ml和190 ml。结果表明，短期暴露于与交通相关的空气污染会降低肺功能指标值并增加氧化应激。这可能会对儿童肺部产生不利影响。
