Darusman Huda S, Agungpriyono Dewi Ratih, Kusumaputri Vinka A, Sajuthi Dondin, Schapiro Steven J, Hau Jann
Faculty of Veterinary Medicine, Bogor Agricultural University (IPB), Bogor, Indonesia.
Primate Research Center, IPB, Bogor, Indonesia.
Front Aging Neurosci. 2019 Mar 7;11:50. doi: 10.3389/fnagi.2019.00050. eCollection 2019.
Neurons with histopathological changes consistent with granulovacuolar degeneration (GVD) were found in brain sections from aged cynomolgus monkeys () with clinical and pathological signs of cognitive aging. To our knowledge, this is the first reported description of GVD in non-human primates. GVD-like lesions were found also in age-matched cognitively healthy subjects, albeit in lower numbers, suggesting that they may relate to aging and the increase may have tendency to increase with the memory deficits. The increased incidence of GVD-like lesions in memory-impaired subjects with pahological backgrounds of senile plaques (SPs) and tauopathy is, however, an interesting observation of relevance to the characterization of pathologies in the spontaneous cynomolgus monkey model of human Alzheimer's type of brain pathology.
在患有认知衰老临床和病理体征的老年食蟹猴的脑切片中发现了具有与颗粒空泡变性（GVD）一致的组织病理学变化的神经元。据我们所知，这是首次报道非人类灵长类动物中的GVD。在年龄匹配的认知健康受试者中也发现了类似GVD的病变，尽管数量较少，这表明它们可能与衰老有关，并且随着记忆缺陷可能有增加的趋势。然而，在具有老年斑（SPs）和tau蛋白病病理背景的记忆受损受试者中，类似GVD病变的发生率增加是一个有趣的观察结果，与人类阿尔茨海默病类型脑病理的自发食蟹猴模型中的病理特征相关。
