Gutiérrez-Repiso Carolina, Moreno-Indias Isabel, de Hollanda Ana, Martín-Núñez Gracia María, Vidal Josep, Tinahones Francisco J
Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga Málaga, Spain.
Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición, CIBERobn Madrid, Spain.
Am J Transl Res. 2019 Feb 15;11(2):942-952. eCollection 2019.
Bariatric surgery (BS) success rates vary in the long-time. A better understanding of weight-loss response may help improve the outcomes of BS. Gut microbiome could be implicated in the successful rate of BS. The aim of the study is to analyze the role of gut microbiome in the successful rate of BS. This is a cross-sectional study of a prospective cohort of 24 patients who underwent gastric bypass. Patients were classified based on excess weight loss (EWL) as: Success (EWL50% at nadir weight and throughout follow-up), Primary Failure (EWL<50% at nadir weight and thereafter), and Weight Regain (EWL>50% at nadir weight, but <50% at last follow-up visit). Gut microbiome analysis was assessed by High Throughput Sequencing. Cholesterol metabolism was shown as the most affected parameter among groups. Studied groups registered minor changes between their gut microbiome abundances, with and among them. However, Success group shared a more diverse core microbiome than the other groups. We showed evidence of a possible role of gut microbiome in the cholesterol metabolism, possibly through bile acids, relative to the success or failure of BS outcomes. and from Primary Failure core microbiome, could have implications in its successful rate. abundance was presented as the best genera related to the body mass index (BMI) post-surgery. Gut microbiota could mediate, at least partially, the success rate of BS through their interaction with the bile acids milieu. Further studies are necessary to validate this probe of concept.
减肥手术（BS）的成功率长期来看存在差异。更好地了解体重减轻反应可能有助于改善减肥手术的效果。肠道微生物群可能与减肥手术的成功率有关。本研究的目的是分析肠道微生物群在减肥手术成功率中的作用。这是一项对24例接受胃旁路手术的前瞻性队列患者的横断面研究。根据体重减轻情况将患者分为：成功组（最低点体重及整个随访期间体重减轻超过50%）、原发性失败组（最低点体重时体重减轻<50%，此后一直如此）和体重反弹组（最低点体重时体重减轻>50%，但最后一次随访时<50%）。通过高通量测序评估肠道微生物群分析。胆固醇代谢是各组中受影响最大的参数。研究组的肠道微生物群丰度之间变化较小，其中有 和 。然而，成功组比其他组共享更多样化的核心微生物群。我们发现肠道微生物群可能通过胆汁酸在胆固醇代谢中发挥作用，这与减肥手术结果的成功或失败有关。原发性失败核心微生物群中的 和 可能对其成功率有影响。 丰度被认为是与术后体重指数（BMI）相关的最佳菌属。肠道微生物群可能至少部分地通过与胆汁酸环境的相互作用来调节减肥手术的成功率。需要进一步研究来验证这一概念验证。
