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外泌体 microRNA：革命性的内源性纳米技术。

Exosomal microRNA: The revolutionary endogenous nanotechnology.

机构信息

Department of Medicine, Albert Einstein College of Medicine, Montefiore University Hospital, New York, NY 10461, USA. Department of Advanced Biomedical Sciences, "Federico II" University of Naples, Naples 80131, Italy.

出版信息

Sci Transl Med. 2018 Nov 14;10(467). doi: 10.1126/scitranslmed.aav9141.

DOI:10.1126/scitranslmed.aav9141
PMID:30899414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6424121/
Abstract

T lymphocytes release exosomes containing specific microRNAs that cause apoptosis of pancreatic β cells in type 1 diabetes.

摘要

T 淋巴细胞释放含有特定 microRNAs 的外泌体，导致 1 型糖尿病中胰岛 β 细胞凋亡。

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Exosomal microRNA: The revolutionary endogenous nanotechnology.外泌体 microRNA：革命性的内源性纳米技术。
Sci Transl Med. 2018 Nov 14;10(467). doi: 10.1126/scitranslmed.aav9141.
2
Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells.外泌体微小RNA的水平转移在胰腺β细胞之间传递凋亡信号。
Cell Commun Signal. 2015 Mar 19;13:17. doi: 10.1186/s12964-015-0097-7.
3
Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development.淋巴细胞衍生的外泌体 microRNAs 促进胰腺 β 细胞死亡，并可能导致 1 型糖尿病的发生。
Cell Metab. 2019 Feb 5;29(2):348-361.e6. doi: 10.1016/j.cmet.2018.09.011. Epub 2018 Oct 11.
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Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress.胰腺分泌的外泌体微小RNA-15a通过诱导氧化应激加重糖尿病并发症。
Antioxid Redox Signal. 2017 Nov 1;27(13):913-930. doi: 10.1089/ars.2016.6844. Epub 2017 Mar 17.
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Dissecting the theranostic potential of exosomes in autoimmune disorders.剖析外泌体在自身免疫性疾病中的诊疗潜力。
Cell Mol Immunol. 2019 Dec;16(12):935-936. doi: 10.1038/s41423-019-0310-5. Epub 2019 Oct 16.
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Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomal MicroRNAs Suppress Myofibroblast Differentiation by Inhibiting the Transforming Growth Factor-β/SMAD2 Pathway During Wound Healing.脐带间充质干细胞来源的外泌体微小RNA在伤口愈合过程中通过抑制转化生长因子-β/SMAD2信号通路抑制肌成纤维细胞分化。
Stem Cells Transl Med. 2016 Oct;5(10):1425-1439. doi: 10.5966/sctm.2015-0367. Epub 2016 Jul 7.
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Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes.1型糖尿病中通过微小RNA介导的TRAIL和Fas凋亡调控实现自身反应性T淋巴细胞存活
Genes Immun. 2016 Sep;17(6):342-8. doi: 10.1038/gene.2016.29. Epub 2016 Jul 28.
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Exosomes as new players in metabolic organ cross-talk.外泌体作为代谢器官对话的新角色。
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Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway.胰腺癌细胞来源的外泌体通过 PI3K/Akt/FoxO1 通路诱导 C2C12 肌管细胞胰岛素抵抗。
Sci Rep. 2017 Jul 14;7(1):5384. doi: 10.1038/s41598-017-05541-4.
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Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.原代人源和大鼠β细胞在外泌体中释放细胞内自身抗原GAD65、IA-2和胰岛素原，同时释放细胞因子诱导的免疫增强因子。
Diabetes. 2017 Feb;66(2):460-473. doi: 10.2337/db16-0671. Epub 2016 Nov 21.

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