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花粉诱发季节性过敏性哮喘的临床与机制研究进展

Advances in the clinical and mechanism research of pollen induced seasonal allergic asthma.

作者信息

Xie Zhi-Juan, Guan Kai, Yin Jia

机构信息

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730, P.R. China.

Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases Beijing 100730, P.R. China.

出版信息

Am J Clin Exp Immunol. 2019 Feb 15;8(1):1-8. eCollection 2019.

PMID:30899604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6420698/
Abstract

Seasonal allergic asthma prevalence has been increasing over the last decades and is one of global health concerns now. Pollen is one of the main reasons to cause seasonal allergic asthma and influenced by multiple risk factors. Thunderstorm-related asthma is a typical type of seasonal allergic asthma that thunderstorms occurring can induce severe asthma attacks during pollen season. The diagnosis of seasonal allergic asthma relies on precise medical history, skin prick tests (SPT) and specific IgE detection. Component resolved diagnosis is greatly significant in determining the complex situation. Allergen specific immunotherapy (AIT) is the only disease-modifying therapy that can change the natural course from seasonal allergic rhinitis to seasonal allergic asthma.

摘要

在过去几十年中，季节性过敏性哮喘的患病率一直在上升，如今已成为全球健康问题之一。花粉是导致季节性过敏性哮喘的主要原因之一，且受多种风险因素影响。雷暴相关哮喘是季节性过敏性哮喘的一种典型类型，在花粉季节，雷暴的发生可诱发严重的哮喘发作。季节性过敏性哮喘的诊断依赖于精确的病史、皮肤点刺试验（SPT）和特异性IgE检测。组分解析诊断对于确定复杂情况具有重要意义。变应原特异性免疫疗法（AIT）是唯一一种可改变从季节性过敏性鼻炎到季节性过敏性哮喘自然病程的疾病改善疗法。

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本文引用的文献

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How Do Storms Affect Asthma?风暴如何影响哮喘？
Curr Allergy Asthma Rep. 2018 Mar 24;18(4):24. doi: 10.1007/s11882-018-0775-9.
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ILC2 frequency and activity are inhibited by glucocorticoid treatment via STAT pathway in patients with asthma.哮喘患者中，糖皮质激素通过 STAT 通路抑制 ILC2 的频率和活性。
Allergy. 2018 Sep;73(9):1860-1870. doi: 10.1111/all.13438.
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External exposome and allergic respiratory and skin diseases.外暴露组与过敏性呼吸和皮肤疾病。
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Interventions for autumn exacerbations of asthma in children.儿童秋季哮喘加重的干预措施。
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induction of T regulatory cells by a methylated CpG DNA sequence in humans: Potential therapeutic applications in allergic and autoimmune diseases.人源甲基化CpG DNA序列诱导调节性T细胞：在变应性和自身免疫性疾病中的潜在治疗应用
Allergy Asthma Proc. 2018 Mar 1;39(2):143-152. doi: 10.2500/aap.2018.39.4113.
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Modified Allergens for Immunotherapy.变应原免疫治疗。
Curr Allergy Asthma Rep. 2018 Feb 16;18(2):9. doi: 10.1007/s11882-018-0766-x.
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Front Immunol. 2018 Jan 30;9:35. doi: 10.3389/fimmu.2018.00035. eCollection 2018.
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