妊娠糖尿病和巨大儿易导致黎巴嫩人群患糖尿病。
Gestational diabetes mellitus and macrosomia predispose to diabetes in the Lebanese population.
作者信息
Ghassibe-Sabbagh Michella, Mehanna Zeina, Farraj Layal Abi, Salloum Angelique K, Zalloua Pierre A
机构信息
Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon.
School of Medicine, Lebanese American University, Beirut, Lebanon.
出版信息
J Clin Transl Endocrinol. 2019 Feb 20;16:100185. doi: 10.1016/j.jcte.2019.100185. eCollection 2019 Jun.
AIMS
The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% of its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational Diabetes Mellitus (GDM), and macrosomia as risk factors of T2DM in Lebanon. Such epidemiological and statistical study has never been conducted before in the Middle East region and would be useful for clinical diagnosis.
METHODS
Our cohort is comprised of 1453 Lebanese individuals, with 897 controls and 556 patients. We tested the correlation between T2DM and the covariates GDM, PCOS, and macrosomia independently. We conducted multinomial logistic regression and cross tabulations with T2DM as an outcome.
RESULTS
The results showed a significant association of the independent factors GDM and macrosomia with T2DM. The risk of having T2DM was increased by 4.192 times with the GDM, and by 2.315 times with macrosomia respectively.
CONCLUSION
In conclusion, GDM and macrosomia, but not PCOS, are significant risk factors for T2DM in our Lebanese cohort. Our results, reported for the first time in the Middle East, present insights into risk factors management and disease prevention.
目的
中东地区是全球2型糖尿病（T2DM）发病率上升最快的地区，黎巴嫩有15.8%的人口受其影响。本研究旨在探究多囊卵巢综合征（PCOS）、妊娠期糖尿病（GDM）和巨大儿作为黎巴嫩T2DM危险因素的情况。中东地区此前从未进行过此类流行病学和统计学研究，该研究对临床诊断将有所帮助。
方法
我们的队列由1453名黎巴嫩人组成，其中897名对照者和556名患者。我们分别测试了T2DM与协变量GDM、PCOS和巨大儿之间的相关性。我们以T2DM为结果进行了多项逻辑回归和交叉表分析。
结果
结果显示，独立因素GDM和巨大儿与T2DM之间存在显著关联。患有GDM时患T2DM的风险增加4.192倍，患有巨大儿时患T2DM的风险增加2.315倍。
结论
总之，在我们的黎巴嫩队列中，GDM和巨大儿是T2DM的重要危险因素，而PCOS不是。我们的研究结果首次在中东地区报道，为危险因素管理和疾病预防提供了见解。
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