Ahmadipour Shokoufeh, Mohsenzadeh Azam, Alimadadi Hosein, Salehnia Mehdi, Fallahi Arash
Department of Pediatrics, Lorestan University of Medical Sciences, Khorramabad, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pediatr Gastroenterol Hepatol Nutr. 2019 Mar;22(2):162-170. doi: 10.5223/pghn.2019.22.2.162. Epub 2019 Mar 11.
The aim of this study was to analyze the effects of probiotics and zinc supplements on the mean duration and frequency of acute diarrhea in children aged 6 months to 2 years.
In this clinical trial of infants aged between 6 months and 2 years, eligible patients were divided into 3 groups: Zinc Receiving Group (ZRG), Probiotic Receiving Group (PRG), and a control group receiving supportive care alone. The frequency of diarrhea was evaluated in the test groups during the first 24 hours and 48-72 hours, along with the duration of hospitalization and diarrhea persistence for 3-7 days.
Diarrhea persisted for until the third day of admission in 100% of the infants in PRG compared with only 76.1% in ZRG. The relative risk of diarrhea persistence in the PRG was 1.31 times more than in ZRG until the third day. Also, 80% of diarrhea cases in the PRG persisted until the fourth day of admission, compared with 47.8% in the ZRG group, and this value was significant. The relative incidence of diarrhea persistence in the PRG was 36.4 times greater than in the ZRG until the day 4. Also, the percentage of post-treatment complications was 35.5% in the PRG and 2.6% in the ZRG, which was significant.
In our study, the effectiveness of zinc at a dose of 20 mg was higher than that of probiotics. The complications associated with zinc supplementation were lower than those of probiotics.
本研究旨在分析益生菌和锌补充剂对6个月至2岁儿童急性腹泻平均持续时间和频率的影响。
在这项针对6个月至2岁婴儿的临床试验中，符合条件的患者被分为3组：锌摄入组（ZRG）、益生菌摄入组（PRG）和仅接受支持性护理的对照组。在试验组中，于最初24小时、48 - 72小时评估腹泻频率，同时评估住院时间和腹泻持续3 - 7天的情况。
PRG组100%的婴儿腹泻持续至入院第三天，而ZRG组仅为76.1%。直到第三天，PRG组腹泻持续的相对风险比ZRG组高1.31倍。此外，PRG组80%的腹泻病例持续至入院第四天，而ZRG组为47.8%，这一差异具有统计学意义。直到第四天，PRG组腹泻持续的相对发生率比ZRG组高36.4倍。而且，PRG组治疗后并发症的百分比为35.5%，ZRG组为2.6%，差异具有统计学意义。
在我们的研究中，20毫克剂量的锌的有效性高于益生菌。与补充锌相关的并发症低于益生菌。
