抗生素治疗对医疗保健相关脑室炎和脑膜炎微生物培养阳性率的影响。
Impact of Antibiotic Therapy in the Microbiological Yield of Healthcare-Associated Ventriculitis and Meningitis.
作者信息
Rogers Thomas, Sok Kevin, Erickson Timothy, Aguilera Elizabeth, Wootton Susan H, Murray Kristy O, Hasbun Rodrigo
机构信息
Infectious Disease Division, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center in Houston, Houston, Texas.
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
出版信息
Open Forum Infect Dis. 2019 Feb 6;6(3):ofz050. doi: 10.1093/ofid/ofz050. eCollection 2019 Mar.
Abstract
The impact of antibiotic therapy on the diagnosis of healthcare-associated ventriculitis and meningitis (HCAVM) is unknown. Antibiotics were administered before obtaining cerebrospinal fluid (CSF) in 217 out of 326 (66%) patients with HCAVM, and they impacted the sensitivity of the cerebrospinal fluid Gram stain and culture ( ≤ .004).
摘要
抗生素治疗对医疗相关脑室炎和脑膜炎（HCAVM）诊断的影响尚不清楚。在326例HCAVM患者中，有217例（66%）在获取脑脊液（CSF）之前就使用了抗生素，这影响了脑脊液革兰氏染色和培养的敏感性（≤.004）。
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J Am Geriatr Soc. 2017 Dec;65(12):2646-2650. doi: 10.1111/jgs.15099. Epub 2017 Oct 4.
2
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3
Development of a prediction rule for diagnosing postoperative meningitis: a cross-sectional study.术后脑膜炎预测规则的制定：一项横断面研究。
J Neurosurg. 2018 Jan;128(1):262-271. doi: 10.3171/2016.10.JNS16379. Epub 2017 Mar 10.
4
2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis.2017年美国传染病学会医疗相关脑室炎和脑膜炎临床实践指南。
Clin Infect Dis. 2017 Mar 15;64(6):e34-e65. doi: 10.1093/cid/ciw861.
5
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Curr Infect Dis Rep. 2016 Nov;18(11):34. doi: 10.1007/s11908-016-0541-x.
6
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Acta Neurochir (Wien). 2016 Sep;158(9):1647-54. doi: 10.1007/s00701-016-2890-5. Epub 2016 Jul 25.
7
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8
Nosocomial ventriculitis and meningitis in neurocritical care patients.神经重症监护患者的医院获得性脑室炎和脑膜炎
J Neurol. 2008 Nov;255(11):1617-24. doi: 10.1007/s00415-008-0059-8. Epub 2008 Dec 8.
9
Antibiotic treatment delay and outcome in acute bacterial meningitis.急性细菌性脑膜炎的抗生素治疗延迟与预后
J Infect. 2008 Dec;57(6):449-54. doi: 10.1016/j.jinf.2008.09.033. Epub 2008 Nov 9.
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Pediatrics. 2008 Oct;122(4):726-30. doi: 10.1542/peds.2007-3275.
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