Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
University of Pavia, Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, and University of Pavia, PhD in Experimental Medicine, Pavia, Italy.
Clin Exp Rheumatol. 2019 Mar-Apr;37(2):167-178. Epub 2019 Mar 19.
Spondyloarthritis (SpA) is an inflammatory condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features that genetically tend to be associated with the major histocompatibility complex class 1 antigen, HLA-B27, and in which both peripheral and axial joints might be affected. In addition to arthritis, the typical musculoskeletal manifestations are enthesitis and dactylitis. Extraarticular manifestations such as acute anterior uveitis (AAU), psoriasis (PsO) and inflammatory bowel disease (IBD) are also typical of SpA. In this article we have reviewed the literature of the past year on one of the most important variants of SpA, i.e. psoriatic arthritis (PsA) (Medline search of articles published from 1st January 2018 to 31st January 2019).
脊柱关节炎(SpA)是一种炎症性疾病,其特征为临床表现、实验室异常和影像学特征广泛,这些特征在遗传上往往与主要组织相容性复合体 1 抗原 HLA-B27 相关,外周和中轴关节均可受累。除关节炎外,典型的肌肉骨骼表现为附着点炎和指(趾)炎。关节外表现如急性前葡萄膜炎(AAU)、银屑病(PsO)和炎症性肠病(IBD)也是 SpA 的典型表现。本文复习了过去一年关于 SpA 中最重要的一个变体,即银屑病关节炎(PsA)的文献(从 2018 年 1 月 1 日至 2019 年 1 月 31 日发表的文章的 Medline 检索)。