Dablouk Mohammed O, O'Halloran Philip J, Faul Clare, Beausang Alan, Rawluk Daniel
Clin Neuropathol. 2019 Jul/Aug;38(4):195-201. doi: 10.5414/NP301158.
Papillary thyroid carcinoma (PTC) is the most common form of well-differentiated thyroid carcinoma. Despite its well-differentiated microscopic features, PTC may be minimally or overtly invasive. We present the case of a patient in whom thoracic spinal cord compression was the first presentation of metastatic PTC.
A 65-year-old woman presented with deteriorating mobility over a 2-month period. Her past history was significant for a right hemithyroidectomy 10 years prior. Examination revealed bilateral lower limb weakness, worse on the right side. Investigations showed a large extradural contrast-enhancing mass at the T7 spinal level. Laminectomy and debulking of this lesion was undertaken. Histopathological examination revealed PTC. The patient proceeded to further treatment with external beam radiotherapy.
DISCUSSION: Spinal metastases are an unusual presentation of PTC. Further research into the outcomes for these patients is imperative to bettering our ability to care for these patients through a multi-modality approach. .
乳头状甲状腺癌(PTC)是分化型甲状腺癌最常见的形式。尽管其在显微镜下具有良好的分化特征,但PTC可能有微小或明显的侵袭性。我们报告一例患者,其胸椎脊髓压迫是转移性PTC的首发表现。
一名65岁女性在2个月内出现活动能力恶化。她的既往史中有10年前行右侧甲状腺次全切除术。检查发现双侧下肢无力,右侧更严重。检查显示在T7脊髓水平有一个大的硬膜外强化肿块。对该病变进行了椎板切除术和减瘤手术。组织病理学检查显示为PTC。患者随后接受了外照射放疗的进一步治疗。
脊髓转移是PTC的一种不寻常表现。对这些患者的预后进行进一步研究对于通过多模式方法提高我们护理这些患者的能力至关重要。