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转移性甲状腺乳头状癌继发胸段脊髓压迫:一种罕见的肿瘤学现象。

Thoracic Spinal Cord Compression Secondary to Metastatic Papillary Thyroid Carcinoma: An Unusual Oncological Phenomenon.

作者信息

Saad Eltaib A, Abdalla Monzer, Awadelkarim Abdalaziz M, Elkhider Osama, Agab Mohamed, Babkir Akram, Idris Isra, Filipiuk Dorota

机构信息

Internal Medicine, AMITA Health Saint Francis Hospital, Evanston, USA.

Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

出版信息

Cureus. 2022 Apr 17;14(4):e24206. doi: 10.7759/cureus.24206. eCollection 2022 Apr.

Abstract

Hematogenous spread is fairly an unusual feature for papillary thyroid carcinoma (PTC) in comparison to follicular thyroid carcinoma (FTC). Thoracic spinal metastasis with complicating cord compression is an even rarer manifestation of PTC that was reported in a limited number of cases in the literature. Herein we present a 65-year-old female with a history of PTC on current radiotherapy, status post attempted surgery due to significant tumor burden and intraoperative bleeding, presented with a one-week history of rapidly progressive bilateral lower extremities weakness. Physical examination revealed paraplegia of both lower extremities with areflexia and a sensory level equivalent to the upper thoracic vertebrae. Urgent imaging depicted destructive epidural lesions at T1-T3 vertebrae with thoracic cord compression. Emergent laminectomy and debulking of these lesions were undertaken. Histopathological examination confirmed metastatic PTC. The patient proceeded to further treatment with radiotherapy following her successful neurological recovery. Thoracic vertebral metastasis is an unusual oncological phenomenon of PTC. Metastatic PTC should be considered in patients with a current or remote history of PTC who present with thoracic cord compression. Our case demonstrates that multidisciplinary management is the key to achieving a better outcome for metastatic PTC with thoracic cord compression.

摘要

与滤泡状甲状腺癌(FTC)相比,血行播散对于乳头状甲状腺癌(PTC)来说是相当不常见的特征。胸椎转移并伴有脊髓受压是PTC更为罕见的一种表现,文献中仅有少数病例报道。在此,我们报告一名65岁女性,有PTC病史,目前正在接受放疗,此前因肿瘤负荷大及术中出血而手术未遂,现出现双下肢快速进行性无力1周病史。体格检查发现双下肢截瘫,无反射,感觉平面相当于胸椎上段。紧急影像学检查显示T1 - T3椎体有破坏性硬膜外病变并伴有胸段脊髓受压。遂紧急进行椎板切除术并切除这些病变。组织病理学检查证实为转移性PTC。患者在神经功能成功恢复后继续接受放疗。胸椎转移是PTC一种不常见的肿瘤学现象。对于有PTC现病史或既往史且出现胸段脊髓受压的患者,应考虑转移性PTC。我们的病例表明,多学科管理是实现转移性PTC伴胸段脊髓受压更好治疗效果的关键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80ce/9117847/7ff1831ad7d7/cureus-0014-00000024206-i01.jpg

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引用本文的文献

本文引用的文献

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Clin Neuropathol. 2019 Jul/Aug;38(4):195-201. doi: 10.5414/NP301158.
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