miR-155-5p 和 miR-760 介导放射疗法抑制非小细胞肺癌细胞的恶性程度。
miR-155-5p and miR-760 mediate radiation therapy suppressed malignancy of non-small cell lung cancer cells.
机构信息
Department of Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Department of Medical Oncology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.
出版信息
Biofactors. 2019 May;45(3):393-400. doi: 10.1002/biof.1500. Epub 2019 Mar 22.
MicroRNAs (miRNAs) play important roles in tumorigenesis of various cancers. Recent study suggested that miRNAs are involved in the therapeutic functions of radiation during cancer treatment. We found that radiation can decrease the migration and invasion of non-small cell lung cancer (NSCLC) cells. Mechanistically, radiation can significantly increase the expression of miR-155-5p and miR-760 in NSCLC cells. Knockdown of miR-155-5p and miR-760 can attenuate radiation suppressed proliferation of NSCLC cells. Among the various targets of miR-155-5p, radiation can decrease the expression of HIF-1α. Similarly, radiation can also suppress the expression of IL-6 via a miR-760 dependent pathway. Gain and loss of function studies confirmed that both HIF-1α and IL-6 were involved in the radiation suppressed proliferation of NSCLC cells. Collectively, our data showed that radiation can regulate the expression of miR-155-5p and miR-760 to suppress the malignancy of NSCLC cells. © 2019 BioFactors, 45(3):393-400, 2019.
微小 RNA（miRNAs）在各种癌症的肿瘤发生中发挥重要作用。最近的研究表明，miRNAs 参与癌症治疗中放射治疗的治疗功能。我们发现，放射治疗可以降低非小细胞肺癌（NSCLC）细胞的迁移和侵袭。从机制上讲，放射治疗可显著增加 NSCLC 细胞中 miR-155-5p 和 miR-760 的表达。miR-155-5p 和 miR-760 的敲低可减弱放射抑制 NSCLC 细胞增殖的作用。在 miR-155-5p 的各种靶标中，放射治疗可降低 HIF-1α 的表达。同样，放射治疗也可以通过 miR-760 依赖途径抑制 IL-6 的表达。获得和功能丧失研究证实，HIF-1α 和 IL-6 均参与放射抑制 NSCLC 细胞增殖。总之，我们的数据表明，放射治疗可以调节 miR-155-5p 和 miR-760 的表达，从而抑制 NSCLC 细胞的恶性程度。©2019 BioFactors，45（3）：393-400，2019。
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