Laboratory of Immunophysiology, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Curr Opin Pharmacol. 2019 Aug;47:53-58. doi: 10.1016/j.coph.2019.02.005. Epub 2019 Mar 20.
Adenosine triphosphate (ATP) is released from host cells during parasite infections and acts as a danger signal in the extracellular space by activating plasma membrane purinergic type 2 receptors-P2 receptors. The activation of these receptors has been described as a crucial step in immune cell activation, inflammation and parasite control. The P2X7 receptor is most involved in the activation of host microbicidal mechanisms, including production of reactive oxygen and nitrogen species, phagolysosomal fusion, acidification of parasitophorous vacuoles and release of cytokines and chemokines. The P2X7 receptor also modulates adaptive immune responses in various infectious diseases. Here, we discuss key points from the recent literature regarding P2X7 receptor activation during intracellular parasite infections.
三磷酸腺苷（ATP）在寄生虫感染过程中从宿主细胞中释放出来，并通过激活质膜嘌呤能 2 型受体（P2 受体）在细胞外空间中充当危险信号。这些受体的激活被描述为免疫细胞激活、炎症和寄生虫控制的关键步骤。P2X7 受体最参与宿主杀菌机制的激活，包括活性氧和氮物种的产生、吞噬溶酶体融合、吞噬体空泡酸化以及细胞因子和趋化因子的释放。P2X7 受体还调节各种感染性疾病中的适应性免疫反应。在这里，我们讨论了最近文献中关于细胞内寄生虫感染过程中 P2X7 受体激活的要点。
