Laboratory of Immunophysiology, Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Biochem Pharmacol. 2021 May;187:114405. doi: 10.1016/j.bcp.2021.114405. Epub 2021 Jan 3.
Purinergic signalling is an evolutionarily conserved signalling pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides released from host cells during intracellular pathogen infections activate plasma membrane purinergic type 2 receptors (P2 receptors) that stimulate microbicidal mechanisms in host innate immune cells. P2X ion channels and P2Y G protein-coupled receptors are involved in activating host innate immune defence mechanisms, phagocytosis, phagolysosomal fusion, production of reactive species, acidification of parasitophorous vacuoles, inflammasome activation, and the release of cytokines, chemokines, and other inflammatory mediators. In this review, as part of a special issue in tribute to Geoffrey Burnstock, we discuss advances in understanding the importance of P2 receptors in the host antimicrobial innate mechanisms against intracellular pathogen infections.
嘌呤能信号转导是一种进化上保守的信号通路，由细胞外核苷酸和核苷介导。细胞内病原体感染过程中从宿主细胞中释放的三磷酸和二磷酸核苷激活质膜嘌呤能 2 型受体（P2 受体），刺激宿主固有免疫细胞中的杀菌机制。P2X 离子通道和 P2Y G 蛋白偶联受体参与激活宿主固有免疫防御机制、吞噬作用、吞噬溶酶体融合、活性物质的产生、吞噬小体酸化、炎性小体激活以及细胞因子、趋化因子和其他炎症介质的释放。在本综述中，作为向杰弗里·伯斯通致敬特刊的一部分，我们讨论了在理解 P2 受体在宿主对抗细胞内病原体感染的抗菌固有机制中的重要性方面的进展。
