Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, and Western University Bone and Joint Institute, University of Western Ontario, London, ON, Canada.
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, and Western University Bone and Joint Institute, University of Western Ontario, London, ON, Canada.
Curr Top Dev Biol. 2019;133:25-47. doi: 10.1016/bs.ctdb.2018.11.003. Epub 2018 Dec 20.
During cartilage development chondrocytes undergo a multi-step process characterized by consecutive changes in cell morphology and gene expression. Cell proliferation, polarity, differentiation, and migration are influenced by chemical and mechanical signaling between the extracellular matrix (ECM) and the cell. Several structurally diverse transmembrane receptors such as integrins, discoidin domain receptor 2 (DDR 2), and CD44 mediate the crosstalk between cells and their ECM. However, the contribution of cell-matrix interactions during early chondrogenesis and further cartilage development through cell receptors and their signal transduction pathways is still not fully understood. Determination of receptor signaling pathways and the function of downstream targets will aid in a better understanding of musculoskeletal pathologies such as chondrodysplasia, and the development of new approaches for the treatment of cartilage disorders. We will summarize recent findings, linking cell receptors and their potential signaling pathways to the control of chondrocyte behavior during early chondrogenesis and endochondral ossification.
在软骨发育过程中，软骨细胞经历一个多步骤的过程，其特征是细胞形态和基因表达的连续变化。细胞增殖、极性、分化和迁移受到细胞外基质（ECM）和细胞之间的化学和机械信号的影响。几种结构多样的跨膜受体，如整合素、盘状结构域受体 2（DDR2）和 CD44，介导细胞与其 ECM 之间的串扰。然而，细胞-基质相互作用在早期软骨发生和进一步软骨发育过程中通过细胞受体及其信号转导途径的贡献仍不完全清楚。确定受体信号通路及其下游靶标的功能将有助于更好地理解肌肉骨骼病理学，如软骨发育不良，以及开发治疗软骨疾病的新方法。我们将总结最近的发现，将细胞受体及其潜在的信号通路与早期软骨发生和软骨内骨化过程中控制软骨细胞行为联系起来。
