预测糖尿病前期个体 HBA1c 变化的延迟折扣作用。
Role of delay discounting in predicting change in HBA1c for individuals with prediabetes.
机构信息
Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Farber Hall, Room G56, 3435 Main Street, Building #26, Buffalo, NY, 14214-3000, USA.
Virginia Tech Carilion Research Institute, Roanoke, USA.
出版信息
J Behav Med. 2019 Oct;42(5):851-859. doi: 10.1007/s10865-019-00026-3. Epub 2019 Mar 22.
Abstract
The majority of people with prediabetes transition to type 2 diabetes. Weight gain is a known predictor of increasing the risk of diabetes, but another reason may be a focus on immediate rewards and discounting of the future. Delay discounting (DD: devaluation of future consequences) is related to obesity and poor glycemic control in persons with type 2 diabetes. This study was designed to assess whether changes in DD are associated with HbA1c change beyond BMI change in individuals with prediabetes. Hierarchical regression showed changes in BMI (p = 0.008) and the $1000 DD task (p = 0.04) were associated with HbA1c change beyond demographic characteristics, with the full model accounting for 25.8% of the variance. Those with greater BMI increases and greater increases in discounting of the future showed the greatest increases in HbA1c. DD represents a novel target to prevent progression from prediabetes to type 2 diabetes.
摘要
大多数糖尿病前期患者会发展为 2 型糖尿病。体重增加是糖尿病风险增加的已知预测因素，但另一个原因可能是关注即时奖励和对未来的贴现。延迟折扣（DD：未来后果的贬值）与 2 型糖尿病患者的肥胖和血糖控制不良有关。本研究旨在评估在糖尿病前期个体中，DD 的变化是否与 BMI 变化以外的 HbA1c 变化相关。分层回归显示 BMI 的变化（p=0.008）和 1000 美元 DD 任务（p=0.04）与人口统计学特征以外的 HbA1c 变化相关，全模型解释了 25.8%的方差。BMI 增加较多和对未来折扣增加较多的患者，HbA1c 增加幅度最大。DD 代表了预防从糖尿病前期进展为 2 型糖尿病的一个新靶点。
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