Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nanomedicine. 2019 Jun;18:221-233. doi: 10.1016/j.nano.2019.02.017. Epub 2019 Mar 21.
Mosquitoes (Diptera; Culicidae) present a major threat to millions of people and animals worldwide, as they act as vectors for various pathogens, especially parasites and viruses. Resistance to insecticides, such as organophosphates and microbial control agents, and insufficient adherence to application guidelines are common reasons for insecticide treatment failure. Therefore, there is an urgent need for exploration of safer, cheaper, and more effective agents, with novel modes of action, to improve mosquito control. Biosynthesized nanoparticles (NPs) have recently been considered as a potential approach for combating vectors of malaria and also as a treatment for malaria. Here, we present current knowledge about the characterization and effectiveness of biogenic NPs against major vectors of malaria, including avian malaria (which may also provide useful insights on vectors of human malaria). This article is the first systematic review of the effects of biosynthesized nanoparticles on both malaria parasites (Plasmodium spp.) and relevant vectors.
蚊子（双翅目；蚊科）对全世界数以百万计的人和动物构成了重大威胁，因为它们是各种病原体的传播媒介，尤其是寄生虫和病毒。对杀虫剂（如有机磷化合物和微生物控制剂）的耐药性以及对应用指南的遵守不足是杀虫剂处理失败的常见原因。因此，迫切需要探索更安全、更便宜、更有效的具有新型作用模式的药物来改善蚊子控制。生物合成的纳米颗粒（NPs）最近被认为是一种有潜力的抗疟疾传播媒介的方法，也可作为疟疾的治疗方法。在这里，我们介绍了生物合成 NPs 对包括禽疟在内的主要疟疾传播媒介的特性和有效性的现有知识（这也可能为人类疟疾的传播媒介提供有用的见解）。本文是对生物合成纳米颗粒对疟原虫（疟原虫属）和相关传播媒介的影响的首次系统综述。
