二氧化钛纳米颗粒的抗原生动物、抗蠕虫和抗媒介活性。

Antiprotozoal, Anthelmintic and Antivectorial Activities of Titanium Dioxide Nanoparticles.

作者信息

Bologna Thainá Silva, de Oliveira Ferrato de Sousa Isabella, do Carmo Neto Jose Rodrigues, de Lima Nunes Thais Amanda, Matos Beatriz Sodre, da Silva Priscilla Elias Ferreira, Guerra Rhanoica Oliveira, Franco Pablo Igor Ribeiro, Machado Juliana Reis, Silva Anielle Christine Almeida, da Silva Marcos Vinicius

机构信息

Department of Microbiology, Immunology and Parasitology, Institute of Biological and Natural Sciences of Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.

Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, GO, Brazil.

出版信息

Curr Med Chem. 2025;32(20):3945-3959. doi: 10.2174/0109298673295600240725060349.

DOI:10.2174/0109298673295600240725060349

PMID:39069809

Abstract

Nanotechnology has been established as a promising alternative for treating a myriad of disease-causing microorganisms that pose threats to human health. The utilization of nanoparticles (NPs) emerges as a strategy to enhance the therapeutic arsenal against these diseases, especially given the tendency of many pathogens to develop resistance to conventional medications. Notably, titanium dioxide nanoparticles (TiONPs) have garnered attention for their multifaceted biomedical applications, encompassing antibacterial, antifungal, antiviral, anticancer, antioxidant, and drug delivery properties. This review focuses on the cutting-edge potential of TiONPs against helminths, protozoa, and vectors, underscoring their pivotal role in combating these health-threatening agents.

摘要

纳米技术已被确立为一种有前景的替代方法，用于治疗对人类健康构成威胁的众多致病微生物。纳米颗粒（NPs）的利用成为增强对抗这些疾病的治疗手段的一种策略，特别是考虑到许多病原体对传统药物产生耐药性的趋势。值得注意的是，二氧化钛纳米颗粒（TiONPs）因其多方面的生物医学应用而受到关注，包括抗菌、抗真菌、抗病毒、抗癌、抗氧化和药物递送特性。本综述重点关注TiONPs对抗蠕虫、原生动物和病媒的前沿潜力，强调它们在对抗这些威胁健康的病原体方面的关键作用。